Bioinspired synthetic polymers-based inhibitors of Alzheimer's amyloid-β peptide aggregation

被引:8
作者
Rupali [1 ]
Joseph, Blessy [2 ]
Thomas, Sabu [2 ]
Sen, Newton [3 ]
Paschold, Andre [3 ]
Binder, Wolfgang H. H. [3 ]
Kumar, Sonu [1 ,4 ]
机构
[1] Punjab Engn Coll Deemed Univ, Dept Appl Sci Chem, Sect 12, Chandigarh 160012, India
[2] Mahatma Gandhi Univ, Sch Energy Mat, Kottayam 686560, Kerala, India
[3] Martin Luther Univ Halle Wittenberg, Dept Chem, D-06120 Halle, Germany
[4] Mahindra Univ, Ecole Cent Sch Engn, Dept Chem, Hyderabad 500043, India
关键词
PROTEIN FIBRILLATION; DRUG-DELIVERY; NANOPARTICLES; FIBRILS; CANCER; RECOGNITION; MODULATION; DENDRIMERS; TOXICITY; DISEASE;
D O I
10.1039/d2py01217k
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no current cure and limited treatment solutions, wherefore discovering of novel therapies remains a global challenge in biopharmaceutical industries. The pathological hallmark of AD is the fibrillogenesis of the amyloid-beta (A beta) peptide, and inhibition of A beta aggregation is considered a primary and effective therapeutic approach to suppress AD progression. For combating this disease bioinspired synthetic macromolecules have been evoked as promising A beta inhibitors, owing to their attractive and optimizable physico-chemical properties and ease of functionalization, in comparison to the other small-molecular analogues. This review article aims to summarize articles documenting synthetic polymer-based inhibitors of A beta aggregations and highlight their potential as promising AD therapeutic agents. Furthermore, the chemical insights into the development of various classes of such polymeric inhibitors, and their modulatory effect on the molecular mechanisms of A beta self-assembly are discussed here to promote advancement in amyloid-related drug discovery research.
引用
收藏
页码:392 / 411
页数:20
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[41]   Alzheimer's-Related Peptide Amyloid-β Plays a Conserved Role in Angiogenesis [J].
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (18) :4184-4188
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[48]   Self-Assembly Molecular Chaperone to Concurrently Inhibit the Production and Aggregation of Amyloid β Peptide Associated with Alzheimer's Disease [J].
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[49]   Interaction between Alzheimer's Amyloid-β and Amyloid-β-Metal Complexes with Cell Membranes [J].
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[50]   Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide [J].
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