Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice

被引：1

作者：

Outeiro, Tiago F. ^{[1
,2
,3
,4
]}

Kalia, Lorraine V. ^{[5
,6
,7
]}

Bezard, Erwan ^{[8
,9
]}

Ferrario, Juan ^{[10
]}

Lin, Chin-Hsien ^{[11
,12
,13
]}

Salama, Mohamed ^{[14
,15
]}

Standaert, David G. ^{[16
]}

Taiwo, Lolade ^{[17
]}

Takahashi, Ryosuke ^{[18
]}

Vila, Miquel ^{[19
,20
,21
]}

Mollenhauer, Brit ^{[4
,21
,22
,23
]}

Svenningsson, Per ^{[21
,24
,25
,26
,27
]}

机构：

[1] Univ Med Ctr Gottingen, Ctr Biostruct Imaging Neurodegenerat, Dept Expt Neurodegenerat, Gottingen, Germany

[2] Max Planck Inst Multidisciplinary Sci, Gottingen, Germany

[3] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, Northumberland, England

[4] Gesell Wissensch Datenverarbeitung Gottingen mbH, Gottingen, Germany

[5] Univ Hlth Network, Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[7] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[8] Univ Bordeaux, Inst Malad Neurodegenerat, Bordeaux, France

[9] CNRS, Unite Mixte Rech 5293, Inst Malad Neurodegenerat, Bordeaux, France

[10] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Inst Biociencias Biotecnol & Biol Traslac iB3, Buenos Aires, Argentina

[11] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan

[12] Natl Taiwan Univ, Inst Mol Med Coll Med, Taipei, Taiwan

[13] Natl Taiwan Univ, Dept Biomed Engn, Taipei, Taiwan

[14] Amer Univ Cairo, Inst Global Hlth & Human Ecol, Cairo, Egypt

[15] Mansoura Univ, Fac Med, Dakahleya, Egypt

[16] Univ Alabama Birmingham, Heersink Sch Med, Dept Neurol, Birmingham, AL USA

[17] Univ Coll Hosp, Dept Neurol, Ibadan, Nigeria

[18] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto, Japan

[19] Autonomous Univ Barcelona, Ctr Biomed Res Neurodegenerat Dis CIBERNED, Vall dHebron Res Inst VHIR Network, Neurodegenerat Dis Res Grp, Barcelona 08035, Spain

[20] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[21] Aligning Sci Parkinsons ASAP, Collaborat Res Network, Chevy Chase, MD USA

[22] Paracelsus Elena Klin, Kassel, Germany

[23] Univ Med Ctr Goettingen, Inst Neurol, Gottingen, Germany

[24] Karolinska Inst, Dept Clin Neurosci & Neurol, Stockholm, Sweden

[25] Karolinska Univ Hosp, Stockholm, Sweden

[26] Kings Coll London, Dept Basic & Clin Neurosci, London, England

[27] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden

来源：

MOVEMENT DISORDERS | 2024年 / 39卷 / 06期

基金：

欧洲研究理事会;

关键词：

basic science; Parkinson's disease; movement disorders; translational research; ALPHA-SYNUCLEIN; PARKINSONISM; TRIAL;

D O I：

10.1002/mds.29802

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel therapies and to establish the basis for personalized medicine. We conclude the viewpoint by a call to action to further improve interactions between clinician and basic scientists. (c) 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

引用

页码：929 / 933

页数：5

共 38 条

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Basic Science SIG, INT PARKINSON MOVEME

[2] 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain [J].