P53 together with ferroptosis: a promising strategy leaving cancer cells without escape

被引：10

作者：

Zhan, Jianhao ^{[1
,2
]}

Wang, Jisheng ^{[1
]}

Liang, Yuqing ^{[3
]}

Zeng, Xiaoping ^{[3
,4
]}

Li, Enliang ^{[1
]}

Wang, Hongmei ^{[3
,4
]}

机构：

[1] Nanchang Univ, Dept Gen Surg, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China

[2] Nanchang Univ, HuanKui Acad, Nanchang 330006, Jiangxi, Peoples R China

[3] Nanchang Univ, Sch Basic Med Sci, Nanchang 330006, Jiangxi, Peoples R China

[4] Jinhua Polytech, Coll Med, Jinhua 321017, Zhejiang, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2024年 / 56卷 / 01期

基金：

中国国家自然科学基金;

关键词：

p53; ferroptosis; lipid peroxidation; ferroptosis signaling; cancer therapy; TEMPERATURE-SENSITIVE MUTANT; TUMOR-SUPPRESSOR; POLYAMINE METABOLISM; EXTRACELLULAR-MATRIX; LIPID-PEROXIDATION; WILD-TYPE; IN-VIVO; ACTIVATION; EXPRESSION; MDM2;

D O I：

10.3724/abbs.2023270

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TP53, functioning as the keeper of the genome, assumes a pivotal function in the inhibition of tumorigenesis. Recent studies have revealed that p53 regulates ferroptosis pathways within tumor cells and is closely related to tumorigenesis. Therefore, we summarize the pathways and mechanisms by which p53 regulates ferroptosis and identify a series of upstream and downstream molecules involved in this process. Furthermore, we construct a p53-ferroptosis network centered on p53. Finally, we present the progress of drugs to prevent wild-type p53 (wtp53) degeneration and restore wtp53, highlighting the deficiencies of drug development and the prospects for p53 in cancer treatment. These findings provide novel strategies and directions for future cancer therapy.

引用

页码：1 / 14

页数：14

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