DNA Methylation in Alcohol Use Disorder

被引：8

作者：

Zheng, Qingmeng ^{[1
]}

Wang, Heng ^{[1
]}

Yan, An ^{[1
]}

Yin, Fangyuan ^{[2
]}

Qiao, Xiaomeng ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Basic Med Sci, Dept Pathol & Forens Med, Zhengzhou 450001, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Forens Sci, Sch Med, Xian 710061, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 12期

基金：

中国国家自然科学基金;

关键词：

alcohol; DNA methylation; gene transcription; age; inhibitors; INDUCED LIVER-INJURY; CPG-BINDING-PROTEIN; METHYLTRANSFERASE INHIBITORS; PREFRONTAL CORTEX; MAMMALIAN DNA; FOLIC-ACID; GENE; CANCER; ASSOCIATION; EXPRESSION;

D O I：

10.3390/ijms241210130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Excessive drinking damages the central nervous system of individuals and can even cause alcohol use disorder (AUD). AUD is regulated by both genetic and environmental factors. Genes determine susceptibility to alcohol, and the dysregulation of epigenome drives the abnormal transcription program and promotes the occurrence and development of AUD. DNA methylation is one of the earliest and most widely studied epigenetic mechanisms that can be inherited stably. In ontogeny, DNA methylation pattern is a dynamic process, showing differences and characteristics at different stages. DNA dysmethylation is prevalent in human cancer and alcohol-related psychiatric disorders, resulting in local hypermethylation and transcriptional silencing of related genes. Here, we summarize recent findings on the roles and regulatory mechanisms of DNA methylation, the development of methyltransferase inhibitors, methylation alteration during alcohol exposure at different stages of life, and possible therapeutic options for targeting methylation in human and animal studies.

引用

页数：16

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