Screening for Latent and Active Tuberculosis in Paediatric Contacts of Tuberculosis Patients: A Cross-sectional Study

被引:0
作者
Narang, Gursharan Singh [1 ]
Malhotra, Preeti [1 ]
Puri, Rahul [1 ]
Kumar, Ashwani [1 ]
机构
[1] SGRDUHS, Dept Paediat, PO Vallah,Mehta Rd, Amritsar, Punjab, India
关键词
Extrapulmonary; Isoniazid; Mantoux; Paucibacillary; Pulmonary; CHILDREN; ADULTS;
D O I
10.7860/JCDR/2023/60860.17996
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Globally, World Health Organisation (WHO) estimate suggests that, one million cases of Tuberculosis (TB) occur among children (approximate 10% of the total 9.6 million TB cases). As per Revised National Tuberculosis Control Programme (RNTCP), high importance and priority is given to the household contacts and paediatric age group (especially <6 years). Since, transmission can happen at any time from index case to the contact (before diagnosis or during treatment), all contacts of TB patients should be screened.Aim: To focus on the screening of paediatric contacts of TB positive patients by Mantoux test and to find out active and latent TB.Materials and Methods: A cross-sectional study was conducted in the Department of Paediatrics at Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India. The duration of the study was 16 months, from February 2020 to June 2021. Participants, who were proven cases, either sputum positive or clinically diagnosed and were less than 18 years of age were included. Contacts in whom Isoniazid Preventive Therapy (IPT) had been started were excluded. The candidates who tested Mantoux positive and had symptoms of TB were further screened by following test chest X-ray, Ultrasonography (USG) abdomen, Microscopy for Acid Fast Bacilli (AFB), Cartridge Based Nucliec Acid Amplification Test (CBNAAT), Cerebrospinal Fluid (CSF) analysis and contrast Magnetic Resonance Imaging (MRI). The data collected was analysed statistically with Statistical Package for Social Sciences (SPSS) version 26.0 and the level of significance was determined p-value <0.05 as insignificant, p-value >0.05 as significant and p-value <0.001 as highly significant.Results: A total of 82 contacts were included. Out of these, 60 children had no organ system involvement, whilst 11 had lymphadenopathy, five had respiratory involvement and six had abdominal involvement. Out of 82 contacts, 23 children tested Mantoux positive and 59 tested negative. Out of 23 Mantoux positive contacts 16 (19.51%) had latent TB and only 1 (2.44%) had active TB.Conclusion: A significant number of children in contact with TB positive patients were found to have latent TB, and it is possible that, there can be activation from latent to active TB later on in these children.
引用
收藏
页码:SC5 / SC9
页数:5
相关论文
共 23 条
  • [11] Karthik AN, 2020, INT J SCI STUDY, V8, P136
  • [12] Kiazyk S, 2017, Can Commun Dis Rep, V43, P62
  • [13] Ministry of Health Family Welfare-Government of India, NAT STRAT PLAN 2017
  • [14] Household Contact Screening and Yield of Tuberculosis Cases-A Clinic Based Study in Chennai, South India
    Nair, Dina
    Rajshekhar, Nandita
    Klinton, Joel Shyam
    Watson, Basilea
    Velayutham, Banurekha
    Tripathy, Jaya Prasad
    Jawahar, Mohideen Shaheed
    Swaminathan, Soumya
    [J]. PLOS ONE, 2016, 11 (09):
  • [15] Programme GT, 2014, GUID NAT TUB PROGR M
  • [16] Sarker NR, 2019, INT J MED RES PROF, V5, P201
  • [17] Sharma KR, 2018, SAARC J TUBERCULOSIS, V16, P33
  • [18] Shital Dhoble Shital Dhoble, 2017, National Journal of Community Medicine, V8, P338
  • [19] Prevalence and risk factors for transmission of infection among children in household contact with adults having pulmonary tuberculosis
    Singh, M
    Mynak, ML
    Kumar, L
    Mathew, JL
    Jindal, SK
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2005, 90 (06) : 624 - 628
  • [20] Tubercular infection in children living with adults receiving Directly Observed Treatment Short Course (DOTS): a follow up study
    Srivastava, Geetika
    Faridi, M. M. A.
    Gupta, Shiv Sagar
    [J]. BMC INFECTIOUS DISEASES, 2020, 20 (01)