Recent advances in the development of Rho kinase inhibitors (2015-2021)

被引：5

作者：

Xu, Xiangrong ^{[1
]}

Yao, Lei ^{[2
,3
]}

机构：

[1] Yantai Univ, Yantai Univ Hosp, Yantai, Peoples R China

[2] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Yantai, Peoples R China

[3] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Yantai 264005, Peoples R China

来源：

MEDICINAL RESEARCH REVIEWS | 2024年 / 44卷 / 01期

关键词：

cancer; inhibitors; patent; progress; ROCK; Rho kinase; ROCK-II INHIBITORS; BIOLOGICAL EVALUATION; VASCULOGENIC MIMICRY; FASUDIL SUPPRESSES; DESIGN; DERIVATIVES; DISCOVERY; PATHWAY; 7-AZAINDOLE; INSIGHTS;

D O I：

10.1002/med.21980

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rho-associated coiled-coil kinases (ROCKs) are key downstream effectors of small GTPases. ROCK plays a central role in diverse cellular events with accumulating evidence supporting the concept that ROCK is important in tumor development and progression. Numerous ROCK inhibitors have been investigated for their therapeutic potential in the treatment of cancers. In this article, we review recent research progress on ROCK inhibitors, especially those with potential for the treatment of cancers, reported in the literature from 2015 to 2021. Most ROCK inhibitors show potent in vitro and in vivo antitumor activities and have potential in the treatment of cancers.

引用

页码：406 / 421

页数：16

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