Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline

被引：3

作者：

Sarkis, Rani A. ^{[1
,3
]}

Gale, Seth A. ^{[1
]}

Yang, Hyun-Sik ^{[1
,2
]}

Lam, Alice D. ^{[2
]}

Singhal, Tarun ^{[1
]}

Cicero, Steven ^{[1
]}

Willment, Kim ^{[1
]}

McGinnis, Scott M. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[3] Brigham & Womens Hosp, Dept Neurol, 60 Fenwood Rd, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2023年 / 38卷

基金：

美国国家卫生研究院;

关键词：

positron emission tomography computed tomography; seizure; ALZHEIMERS-DISEASE; UNPROVOKED SEIZURES; NATIONAL INSTITUTE; ONSET EPILEPSY; ASSOCIATION; DIAGNOSIS; MILD; PET; IMPAIRMENT; PREVALENCE;

D O I：

10.1177/15333175231160005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In older adults with cognitive decline and epilepsy, diagnosing the etiology of cognitive decline is challenging. We identified 6 subjects enrolled in the Imaging Dementia-Evidence of Amyloid Imaging Scanning (IDEAS) study and nonlesional epilepsy. Three cognitive neurologists reviewed each case to determine the likelihood of underlying Alzheimer's disease (AD) pathology. Their impressions were compared to amyloid PET findings. In 3 cases the impression was concordant with PET findings. In 2 cases "possibly suggestive," the PET reduced diagnostic uncertainty, with 1 having a PET without elevated amyloid and the other PET with intermediate amyloid. In the remaining case with lack of reviewer concordance, the significance of PET with elevated amyloid remains uncertain. This case series highlights that in individuals with a history of epilepsy and cognitive decline, amyloid PET can be a useful tool in evaluating the etiology of cognitive decline when used in an appropriate context.

引用

页数：9

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