State of the Art on the Role of Staphylococcus aureus Extracellular Vesicles in the Pathogenesis of Atopic Dermatitis

被引:2
作者
Torrealba, Marina Passos [1 ]
Yoshikawa, Fabio Seiti Yamada [2 ]
Aoki, Valeria [1 ]
Sato, Maria Notomi [1 ]
Orfali, Raquel Leao [1 ]
机构
[1] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Med Invest Dermatol & Immunodeficiencies LIM 5, BR-05403000 Sao Paulo, SP, Brazil
[2] Chiba Univ, Med Mycol Res Ctr, Div Mol Immunol, Chiba 2608670, Japan
基金
巴西圣保罗研究基金会;
关键词
Staphylococcus aureus; extracellular vesicles; atopic dermatitis; microbiota; INDUCED CELL-DEATH; MEMBRANE-VESICLES; METAGENOMIC ANALYSIS; ALPHA-TOXIN; PATHOPHYSIOLOGY; CULTURE;
D O I
10.3390/microorganisms12030531
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Atopic dermatitis (AD) is a chronic and relapsing inflammatory cutaneous disease. The role of host defense and microbial virulence factors in Staphylococcus aureus skin colonization, infection, and inflammation perpetuation in AD remains an area of current research focus. Extracellular vesicles (EV) mediate cell-to-cell communication by transporting and delivering bioactive molecules, such as nucleic acids, proteins, and enzymes, to recipient cells. Staphylococcus aureus spontaneously secretes extracellular vesicles (SA-derived EVs), which spread throughout the skin layers. Previous research has shown that SA-derived EVs from AD patients can trigger cytokine secretion in keratinocytes, shape the recruitment of neutrophils and monocytes, and induce inflammatory AD-type lesions in mouse models, in addition to their role as exogenous worsening factors for the disease. In this review article, we aim to examine the role of SA-derived EVs in AD physiopathology and its progression, highlighting the recent research in the field and exploring the potential crosstalk between the host and the microbiota.
引用
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页数:11
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