Phlorizin, an Important Glucoside: Research Progress on Its Biological Activity and Mechanism

被引：21

作者：

Ni, Tongjia ^{[1
]}

Zhang, Shuai ^{[2
]}

Rao, Jia ^{[1
]}

Zhao, Jiaqi ^{[1
]}

Huang, Haiqi ^{[1
]}

Liu, Ying ^{[1
]}

Ding, Yue ^{[1
]}

Liu, Yaqian ^{[1
]}

Ma, Yuchi ^{[3
]}

Zhang, Shoujun ^{[4
]}

Gao, Yang ^{[5
]}

Shen, Liqian ^{[5
]}

Ding, Chuanbo ^{[1
,3
]}

Sun, Yunpeng ^{[1
]}

机构：

[1] Jilin Agr Sci & Technol Coll, Coll Tradit Chinese Med, Jilin 132101, Peoples R China

[2] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[3] Jilin Aodong Hlth Technol Co Ltd, Yanbian 133700, Peoples R China

[4] Jilin Aodong Yanbian Pharmaceut Co Ltd, Yanbian 133700, Peoples R China

[5] Jilin Jianwei Nat Biotechnol Co Ltd, Linjiang 134600, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 03期

关键词：

phlorizin; extraction and identification; biological activity; mechanism; FATTY LIVER-DISEASE; PREPARATIVE SEPARATION; ANTIOXIDANT ACTIVITY; PHLORETIN; INHIBITION; PURIFICATION; EXPRESSION; DAMAGE; CELLS; TRANSPORTER;

D O I：

10.3390/molecules29030741

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phlorizin, as a flavonoid from a wide range of sources, is gradually becoming known for its biological activity. Phlorizin can exert antioxidant effects by regulating the IL-1 beta/IKB-alpha/NF-KB signaling pathway. At the same time, it exerts its antibacterial activity by reducing intracellular DNA agglutination, reducing intracellular protein and energy synthesis, and destroying intracellular metabolism. In addition, phlorizin also has various pharmacological effects such as antiviral, antidiabetic, antitumor, and hepatoprotective effects. Based on domestic and foreign research reports, this article reviews the plant sources, extraction, and biological activities of phlorizin, providing a reference for improving the clinical application of phlorizin.

引用

页数：13

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