Pd(<sc>ii</sc>)-Catalyzed enantioselective C-H olefination toward the synthesis of P-stereogenic phosphinamides

被引：6

作者：

Chen, Zi-Jia ^{[1
]}

Fan, Ling-Jie ^{[2
]}

Xie, Pei-Pei ^{[1
]}

Qian, Pu-Fan ^{[1
]}

Hu, Xinquan ^{[2
]}

Zhou, Tao ^{[1
,3
]}

Shi, Bing-Feng ^{[1
,3
,4
]}

机构：

[1] Zhejiang Univ, Ctr Chem Frontier Technol, Dept Chem, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China

[3] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Zhejiang, Peoples R China

[4] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 12期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ASYMMETRIC PHOSPHINATION; SECONDARY PHOSPHINE; CHIRAL PHOSPHINES; BRONSTED ACID; FUNCTIONALIZATION; ACTIVATION; LIGANDS; C(SP(2))-H; ARYLATION; DESYMMETRIZATION;

D O I：

10.1039/d3cc05052a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

P-Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd(ii)-catalyzed enantioselective C-H olefination toward the synthesis of P-stereogenic phosphinamides using cheap commercially available l-pGlu-OH as a chiral ligand. A broad range of P-stereogenic phosphinamides were gained in good yields with high enantioselectivities (33 examples, up to 77% yield, 99% ee) via desymmetrization and kinetic resolution.

引用

页码：1623 / 1626

页数：4

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