Targeted Combination Therapies: A New Frontier in the Treatment of TP53 and KRAS Mutation-Associated Cancers

被引：2
作者：
Kargbo, Robert B. [1 ]
机构：
[1] Usona Inst, Fitchburg, WI 53711 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2023年 / 15卷 / 01期
关键词：
D O I：
10.1021/acsmedchemlett.3c00534
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This Patent Highlight discusses novel therapeutic strategies for treating cancers associated with TP53 or KRAS mutations, particularly colorectal, pancreatic, and non-small-cell lung cancers. It focuses on the use of combination therapies involving two distinct compounds and a KRAS inhibitor. Researchers are exploring the effectiveness of these combined therapies in patient treatment and investigating their potential applications in drug manufacturing. With cancer being a global health challenge, these innovative strategies could present a breakthrough in enhancing survival rates and improving the quality of life for patients.
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页码：15 / 16
页数：2
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