The Impact of Exercise Training and Supplemental Oxygen on Peripheral Muscles in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

被引:6
作者
Neunhaeuserer, Daniel [1 ,2 ,5 ]
Hudelmaier, Martin [3 ]
Niederseer, David [1 ,2 ,7 ]
Vecchiato, Marco [5 ]
Wirth, Wolfgang [3 ]
Steidle-kloc, Eva [3 ]
Kaiser, Bernhard [4 ]
Lamprecht, Bernd [4 ,6 ]
Ermolao, Andrea [5 ,8 ]
Studnicka, Michael [4 ]
Niebauer, Josef [1 ,2 ]
机构
[1] Paracelsus Med Univ Salzburg, Univ Inst Sports Med Prevent & Rehabil, Salzburg, Austria
[2] Paracelsus Med Univ Salzburg, Res Inst Mol Sports Med & Rehabil, Salzburg, Austria
[3] Paracelsus Med Univ Salzburg, Inst Anat & Cell Biol, Salzburg, Austria
[4] Paracelsus Med Univ Salzburg, Univ Clin Pneumol, Salzburg, Austria
[5] Univ Padua, Dept Med, Sports & Exercise Med Div, Padua, Italy
[6] Johannes Kepler Univ Linz, Kepler Univ Hosp, Fac Med, Dept Pulm Med, Linz, Austria
[7] Univ Hosp Zurich, Univ Heart Ctr, Dept Cardiol, Zurich, Switzerland
[8] Univ Padua, Dept Med, Sports & Exercise Med Div, Via Giustiniani 2, I-35128 Padua, Italy
关键词
CHRONIC OBSTRUCTIVE PULMONARY DISEASE; HYPEROXIA; PULMONARY REHABILITATION; LIMB MUSCLE DYSFUNCTION; QUADRICEPS FEMORIS MUSCLE; MAGNETIC RESONANCE IMAGING; RESPIRATORY SOCIETY STATEMENT; AMBULATORY OXYGEN; PHYSICAL-ACTIVITY; COPD PATIENTS; REHABILITATION; BENEFITS; INTERVENTION; MORTALITY; HYPEROXIA; IMPROVE;
D O I
10.1249/MSS.0000000000003268
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
ObjectiveExercise training is a cornerstone of the treatment of chronic obstructive pulmonary disease, whereas the related interindividual heterogeneity in skeletal muscle dysfunction and adaptations are not yet fully understood. We set out to investigate the effects of exercise training and supplemental oxygen on functional and structural peripheral muscle adaptation.MethodsIn this prospective, randomized, controlled, double-blind study, 28 patients with nonhypoxemic chronic obstructive pulmonary disease (forced expiratory volume in 1 second, 45.92% +/- 9.06%) performed 6 wk of combined endurance and strength training, three times a week while breathing either supplemental oxygen or medical air. The impact on exercise capacity, muscle strength, and quadriceps femoris muscle cross-sectional area (CSA) was assessed by maximal cardiopulmonary exercise testing, 10-repetition maximum strength test of knee extension, and magnetic resonance imaging, respectively.ResultsAfter exercise training, patients demonstrated a significant increase in functional capacity, aerobic capacity, exercise tolerance, quadriceps muscle strength, and bilateral CSA. Supplemental oxygen affected significantly the training impact on peak work rate when compared with medical air (+0.20 +/- 0.03 vs +0.12 +/- 0.03 W center dot kg-1, P = 0.047); a significant increase in CSA (+3.9 +/- 1.3 cm2, P = 0.013) was only observed in the training group using oxygen. Supplemental oxygen and exercise-induced peripheral desaturation were identified as significant opposing determinants of muscle gain during this exercise training intervention, which led to different adaptations of CSA between the respective subgroups.ConclusionsThe heterogenous functional and structural muscle adaptations seem determined by supplemental oxygen and exercise-induced hypoxia. Indeed, supplemental oxygen may facilitate muscular training adaptations, particularly in limb muscle dysfunction, thereby contributing to the enhanced training responses on maximal aerobic and functional capacity.
引用
收藏
页码:2123 / 2131
页数:9
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