Challenges in prevention, early detection, and management of febrile neutropenia in adult patients with solid tumors

被引:1
作者
Popov, Petar [1 ]
机构
[1] Med Univ Vienna, Div Oncol, Dept Med 1, Waehringer Guertel 18-20, A-1090 Vienna, Austria
关键词
Guidelines; Risk assessment; G-CSF; Genetic factors; Patient education;
D O I
10.1007/s12254-023-00909-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Febrile neutropenia (FN) is a common oncologic emergency where quick patient assessment and prompt initiation of antimicrobial treatment is crucial. Guidelines provide detailed recommendations on prevention and treatment; however, their real-world implementation can prove to be difficult. Score systems for outcome risk are effective in identifying low-risk patients with FN. After initiation of therapy, regular re-evaluation of antimicrobial treatment is necessary, and further diagnostic studies should be tailored to each patient. Use of granulocyte colony-stimulating factor (G-CSF) prophylactically in chemotherapy regimens with intermediate FN risk as well as therapeutically in patients with manifest FN is variable in clinical practice and needs to be better defined. Future steps of reducing risk of FN involve investigating underlying genetic factors. Regarding early detection of FN, patient education is paramount. This short review gives an overview of current guidelines and highlights key challenges in management of FN.
引用
收藏
页码:255 / 258
页数:4
相关论文
共 50 条
[21]   RISK ASSESSMENT, PREVENTION, AND EARLY DETECTION: CHALLENGES FOR THE ADVANCED PRACTICE NURSE [J].
Mahon, Suzanne M. .
SEMINARS IN ONCOLOGY NURSING, 2015, 31 (04) :306-326
[22]   EORTC continues to support the appropriate treatment of adult patients with G-CSF to prevent febrile neutropenia: guideline updates [J].
Clayton, Julie .
GABI JOURNAL-GENERICS AND BIOSIMILARS INITIATIVE JOURNAL, 2013, 2 (01) :47-48
[23]   Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results [J].
Catala, Gaetan ;
Mebis, Jeroen ;
Jerusalem, Guy ;
Verhoeven, Didier ;
Awada, Ahmad ;
Bols, Alain ;
Somers, Luc ;
Van den Broeck, Anke ;
Duhoux, Francois P. ;
Machiels, Jean-Pascal .
ACTA CLINICA BELGICA, 2020, 75 (02) :128-135
[24]   Prospective Audit of Post-chemotherapy Febrile Neutropenia in Patients with Solid Cancer and Lymphoma in Two Singaporean Cancer Centres [J].
Wong, Mabel ;
Jin, Jing ;
Tan, Min Han ;
Lee, Yee Mei ;
Lee, Ten Eng ;
Ding, Ying ;
Yong, Hong Chan ;
Lim, Siew Eng ;
Chai, Louis Y. A. ;
Noan Minh Chau ;
Hsu, Li Yang .
ANNALS ACADEMY OF MEDICINE SINGAPORE, 2012, 41 (07) :287-293
[25]   Cost-effectiveness of pegfilgrastim versus filgrastim for prevention of chemotherapy-induced febrile neutropenia in patients with lymphoma: a systematic review [J].
Gebremariam, Girma Tekle ;
Fentie, Atalay Mulu ;
Beyene, Kebede ;
Sander, Beate ;
Gebretekle, Gebremedhin Beedemariam .
BMC HEALTH SERVICES RESEARCH, 2022, 22 (01)
[26]   Clinical significance of repeat blood cultures during febrile neutropenia in adult acute myeloid leukaemia patients undergoing intensive chemotherapy [J].
Kimura, Shun-ichi ;
Gomyo, Ayumi ;
Hayakawa, Jin ;
Tamaki, Masaharu ;
Akahoshi, Yu ;
Harada, Naonori ;
Ugai, Tomotaka ;
Kusuda, Machiko ;
Kameda, Kazuaki ;
Wada, Hidenori ;
Ishihara, Yuko ;
Kawamura, Koji ;
Sakamoto, Kana ;
Sato, Miki ;
Terasako-Saito, Kiriko ;
Kikuchi, Misato ;
Nakasone, Hideki ;
Kako, Shinichi ;
Tanihara, Aki ;
Kanda, Yoshinobu .
INFECTIOUS DISEASES, 2017, 49 (10) :748-757
[27]   Evaluation of Caspofungin or Micafungin as Empiric Antifungal Therapy in Adult Patients With Persistent Febrile Neutropenia: A Retrospective, Observational, Sequential Cohort Analysis [J].
Kubiak, David W. ;
Bryar, Julie M. ;
McDonnell, Anne M. ;
Delgado-Flores, Jorge O. ;
Mui, Emily ;
Baden, Lindsey R. ;
Marty, Francisco M. .
CLINICAL THERAPEUTICS, 2010, 32 (04) :637-648
[28]   Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia in Adult Patients with Lymphoproliferative Disorders - Clinical Experience in University Hospital of Split [J].
Galusic, Davor ;
Petric, Marija ;
Cutura, Lucana Vicelic ;
Miljak, Antonija ;
Blaslov, Viktor .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 :S242-S243
[29]   Development and validation of a cycle-specific risk score for febrile neutropenia during chemotherapy cycles 2-6 in patients with solid cancers: The CSRFENCE score [J].
Aagaard, Theis ;
Reekie, Joanne ;
Roen, Ashley ;
Daugaard, Gedske ;
Specht, Lena ;
Sengelov, Henrik ;
Mocroft, Amanda ;
Lundgren, Jens ;
Helleberg, Marie .
INTERNATIONAL JOURNAL OF CANCER, 2020, 146 (02) :321-328
[30]   Incidence of febrile neutropenia among early-stage breast cancer patients receiving anthracycline-based chemotherapy [J].
Chan, Alexandre ;
Chen, Christy ;
Chiang, Joen ;
Tan, Sze Huey ;
Ng, Raymond .
SUPPORTIVE CARE IN CANCER, 2012, 20 (07) :1525-1532