Hematopoietic Stem Cell: Regulation and Nutritional Intervention

被引：5
作者：
Sun, Siyuan [1 ]
Han, Yingxue [2 ]
Lei, Yumei [1 ]
Yu, Yifei [1 ]
Dong, Yanbin [3 ]
Chen, Juan [1 ]
机构：
[1] China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100190, Peoples R China
[2] China Agr Univ, Coll Anim Sci & Technol, Natl Engn Lab Anim Breeding, Key Lab Anim Genet, Beijing 100193, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100045, Peoples R China
来源：
NUTRIENTS | 2023年 / 15卷 / 11期
基金：
美国国家科学基金会;
关键词：
hematopoietic stem cell; nutrients; RNA-binding protein; high-fat diet; bone marrow transplantation; PHASE-SEPARATION; GUT MICROBIOTA; SELF-RENEWAL; TRANSPLANTATION; EXPRESSION; DIFFERENTIATION; ENGRAFTMENT; MICE;
D O I：
10.3390/nu15112605
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Hematopoietic stem cells (HSCs) are crucial for the life maintenance of bio-organisms. However, the mechanism of HSC regulation is intricate. Studies have shown that there are various factors, either intrinsically or extrinsically, that shape the profile of HSCs. This review systematically summarizes the intrinsic factors (i.e., RNA-binding protein, modulators in epigenetics and enhancer-promotor-mediated transcription) that are reported to play a pivotal role in the function of HSCs, therapies for bone marrow transplantation, and the relationship between HSCs and autoimmune diseases. It also demonstrates the current studies on the effects of high-fat diets and nutrients (i.e., vitamins, amino acids, probiotics and prebiotics) on regulating HSCs, providing a deep insight into the future HSC research.
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页数：16
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