New therapeutic options against leishmaniasis are necessary, especially those of natural origin, like licarin A, a neolignan with activity against Leishmania major. The effect of licarin A (DL01) and its derivatives (DL03, DL10, DL17 and DL21) was evaluated against Leishmania amazonensis promastigotes and intracellular amastigotes. Promastigote forms were assayed in different incubation periods and the 50% effective concentration (EC50) was determined. Cytotoxicity was assessed in murine peritoneal macrophages by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay to determine the 50.0% cytotoxicity concentrations (CC50). Anti-amastigote activity was evaluated through the effective concentration to amastigotes (EC50ama and EC90ama), and selectivity indexes (SI) were calculated. Lipophilicity (LogP) and mitochondrial membrane potential (Delta psi) were analyzed. DL21 showed a significant anti-promastigote (EC50pro: 4.68 mu M) and anti-amastigote (EC50ama and EC90ama: 0.42 and 15.91 mu M, respectively) activity, and substantial SI (94.73) to amastigotes and an adequate Log P (5.54), while not changing Delta psi. DL21 is a promising drug candidate and further studies are necessary for better understanding licarin A mechanisms of action.
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Alvarenga, Dalila Junqueira
Faria Matias, Laira Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Faria Matias, Laira Maria
Oliveira, Lucas Martins
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Oliveira, Lucas Martins
Melchior de Oliveira Leao, Luiz Paulo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Melchior de Oliveira Leao, Luiz Paulo
Hawkes, Jamie Anthony
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Hawkes, Jamie Anthony
Boas Raimundo, Breno Vilas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Inst Ciencias Biomed, Dept Microbiol & Imunol, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Boas Raimundo, Breno Vilas
Diniz Castro, Livia de Figueiredo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Inst Ciencias Biomed, Dept Microbiol & Imunol, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Diniz Castro, Livia de Figueiredo
Anraku de Campos, Marli Matiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Santa Maria, Dept Analises Clin & Toxicolog, BR-9710590 Santa Maria, RS, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Anraku de Campos, Marli Matiko
Siqueira, Fallon dos Santos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Santa Maria, Dept Analises Clin & Toxicolog, BR-9710590 Santa Maria, RS, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Siqueira, Fallon dos Santos
dos Santos, Thiago
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo, SP, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
dos Santos, Thiago
Carvalho, Diogo Teixeira
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Aquistapase Dagnino, Ana Paula
Mesquita, Camila Saporiti
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Mesquita, Camila Saporiti
Dorneles, Gilson Pires
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Dorneles, Gilson Pires
Nunes Teixeira, Vivian de Oliveira
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Nunes Teixeira, Vivian de Oliveira
Correa de Barros, Francisco Maikon
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Correa de Barros, Francisco Maikon
Ccana-Ccapatinta, Gari Vidal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Ccana-Ccapatinta, Gari Vidal
Fonseca, Simone Goncalves
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Goias, Inst Patol Trop & Saude Publ, BR-74605050 Goiania, Go, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Fonseca, Simone Goncalves
Monteiro, Marta Chagas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Para UFPA, Inst Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-66075110 Belem, Para, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Monteiro, Marta Chagas
Rodrigues Junior, Luiz Carlos
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Rodrigues Junior, Luiz Carlos
Peres, Alessandra
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Reabilitacao, Porto Alegre, RS, Brazil
Ctr Univ Metodista IPA, Rua Coronel Joaquim Pedro Salgado 80, BR-90420060 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Peres, Alessandra
von Poser, Gilsane Lino
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
von Poser, Gilsane Lino
Torres Romao, Pedro Roosevelt
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Biociencias, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
机构:
Fundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, BrazilFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Bastos, Monica M.
Boechat, Nubia
论文数: 0引用数: 0
h-index: 0
机构:
Fundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, BrazilFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Boechat, Nubia
Gomes, Ana T. P. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Gomes, Ana T. P. C.
Neves, Maria G. P. M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Neves, Maria G. P. M. S.
Cavaleiro, Jose A. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Alvarenga, Dalila Junqueira
Faria Matias, Laira Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Faria Matias, Laira Maria
Oliveira, Lucas Martins
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Oliveira, Lucas Martins
Melchior de Oliveira Leao, Luiz Paulo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Melchior de Oliveira Leao, Luiz Paulo
Hawkes, Jamie Anthony
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Hawkes, Jamie Anthony
Boas Raimundo, Breno Vilas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Inst Ciencias Biomed, Dept Microbiol & Imunol, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Boas Raimundo, Breno Vilas
Diniz Castro, Livia de Figueiredo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Inst Ciencias Biomed, Dept Microbiol & Imunol, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Diniz Castro, Livia de Figueiredo
Anraku de Campos, Marli Matiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Santa Maria, Dept Analises Clin & Toxicolog, BR-9710590 Santa Maria, RS, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Anraku de Campos, Marli Matiko
Siqueira, Fallon dos Santos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Santa Maria, Dept Analises Clin & Toxicolog, BR-9710590 Santa Maria, RS, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
Siqueira, Fallon dos Santos
dos Santos, Thiago
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo, SP, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
dos Santos, Thiago
Carvalho, Diogo Teixeira
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, BrazilUniv Fed Alfenas, Fac Ciencias Farmaceut, Dept Alimentos & Medicamentos, Rua Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG, Brazil
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Aquistapase Dagnino, Ana Paula
Mesquita, Camila Saporiti
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Mesquita, Camila Saporiti
Dorneles, Gilson Pires
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Dorneles, Gilson Pires
Nunes Teixeira, Vivian de Oliveira
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Nunes Teixeira, Vivian de Oliveira
Correa de Barros, Francisco Maikon
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Correa de Barros, Francisco Maikon
Ccana-Ccapatinta, Gari Vidal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Ccana-Ccapatinta, Gari Vidal
Fonseca, Simone Goncalves
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Goias, Inst Patol Trop & Saude Publ, BR-74605050 Goiania, Go, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Fonseca, Simone Goncalves
Monteiro, Marta Chagas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Para UFPA, Inst Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-66075110 Belem, Para, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Monteiro, Marta Chagas
Rodrigues Junior, Luiz Carlos
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Rodrigues Junior, Luiz Carlos
Peres, Alessandra
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Reabilitacao, Porto Alegre, RS, Brazil
Ctr Univ Metodista IPA, Rua Coronel Joaquim Pedro Salgado 80, BR-90420060 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
Peres, Alessandra
von Poser, Gilsane Lino
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Av Ipiranga 2752, BR-90610000 Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
von Poser, Gilsane Lino
Torres Romao, Pedro Roosevelt
论文数: 0引用数: 0
h-index: 0
机构:
UFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Ciencias Saude, Porto Alegre, RS, Brazil
UFCSPA, Programa Posgrad Biociencias, Porto Alegre, RS, BrazilUFCSPA, Lab Imunol, Porto Alegre, RS, Brazil
机构:
Fundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, BrazilFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Bastos, Monica M.
Boechat, Nubia
论文数: 0引用数: 0
h-index: 0
机构:
Fundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, BrazilFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Boechat, Nubia
Gomes, Ana T. P. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Gomes, Ana T. P. C.
Neves, Maria G. P. M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil
Neves, Maria G. P. M. S.
Cavaleiro, Jose A. S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Aveiro, Dept Quim, QOPNA, P-3810193 Aveiro, PortugalFundacao Oswaldo Cruz, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, RJ, Brazil