Recent advances towards overcoming the blood-brain barrier

被引：9

作者：

Ali, Amna ^{[1
]}

Arshad, Muhammad Sohail ^{[2
]}

Khan, Mahtab Ahmad ^{[3
]}

Chang, Ming-Wei ^{[4
]}

Ahmad, Zeeshan ^{[1
]}

机构：

[1] Montfort Univ, Leicester Sch Pharm, Leicester, England

[2] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan

[3] Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan

[4] Univ Ulster, Nanotechnol & Integrated Bioengn Ctr, Belfast, North Ireland

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 10期

关键词：

blood-brain barrier; central nervous system; neurological disorders; BBB dysfunction; neuroinflammation; drug delivery systems; neuropharmacology; brain-targeted therapy; DRUG-DELIVERY; TEMOZOLOMIDE; MECHANISMS; CNS;

D O I：

10.1016/j.drudis.2023.103735

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The blood-brain barrier (BBB) is a protective element of the neurovascular unit (NVU) surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex, which play a fundamental role in brain homeostasis. Due to its impeccable structural architecture, the BBB is referred to as the brain's gatekeeper, a near-impenetrable barrier to therapeutics. This review summarises the significant strides that have been made in the last 5 years towards circumventing the BBB and developing efficient drug delivery systems. Challenges associated with several CNS disorders related to BBB failure and exploitation of this unique NVU component for targeted treatment of brain-related disorders are also discussed.

引用

页数：13

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