Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health

被引：9

作者：

Yao, Siqi ^{[1
,2
]}

Zhao, Yiming ^{[2
]}

Chen, Hao ^{[3
]}

Sun, Ruizheng ^{[2
]}

Chen, Liyu ^{[2
]}

Huang, Jing ^{[3
]}

Yu, Zheng ^{[2
]}

Chen, Shuijiao ^{[1
,4
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Peoples R China

[2] Cent South Univ, Sch Basic Med Sci, Dept Microbiol, Changsha 410078, Peoples R China

[3] Cent South Univ, Sch Basic Med Sci, Dept Parasitol, Changsha 410078, Peoples R China

[4] Xiangya Hosp Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China

来源：

NUTRIENTS | 2023年 / 15卷 / 15期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

diet; gut microbiota; gut health; high protein; high fiber; ESCHERICHIA-COLI; REVEALS; NUTRITION; BACTERIA; DISEASE; INFANT; IMPACT; FIBER; TRIAL;

D O I：

10.3390/nu15153460

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Dietary habits have been proven to help alter the composition of gut microbiota, and exploring the impact of nutritional patterns on gut microbiota changes can help protect gut health. However, few studies have focused on the dietary impact on the gut microbiota over an experimental timeframe. In this study, 16S rRNA gene sequencing was employed to investigate the gut microbiota of mice under different dietary patterns, including AIN-93G diet (Control), high protein diet (HPD), high fiber diet (HFD), and switch diet (Switch). The alpha diversity of the HPD group significantly decreased, but HFD can restore this decline. During HPD, some genera were significantly upregulated (e.g., Feacalibaculum) and downregulated (e.g., Parabacteroides). However, after receiving HFD, other genera were upregulated (e.g., Akkermansia) and downregulated (e.g., Lactobacillus). In addition, the interaction between pathogenic bacteria was more pronounced during HPD, while the main effect was probiotics during HFD. In conclusion, the plasticity exhibited by the gut microbiota was subject to dietary influences, wherein disparate dietary regimens hold pivotal significance in upholding the well-being of the host. Therefore, our findings provide new ideas and references for the relationship between diets and gut microbiota.

引用

页数：17