Double, double, TP53, and trouble in myelofibrosis

被引：0

作者：

Krishnamurthy, Pramila ^{[1
]}

机构：

[1] Kings Coll Hosp London, London, England

来源：

BLOOD | 2023年 / 141卷 / 23期

关键词：

D O I：

10.1182/blood.2023020421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Gagelmann and colleagues provide novel insights into the impact of TP53 mutational status on outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelofibrosis (MF).(1) Their observations, which demonstrate that the multi-hit TP53 mutational state predicts adverse outcome following allo-HSCT, are of real practical relevance to transplant physicians counselling prospective recipients. One of their important findings is the identification of a subgroup of patients who have a particularly poor prognosis in spite of allo-HSCT, for whom the MF research community should consider ways to improve the efficacy of this procedure.

引用

页码：2793 / 2795

页数：3

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