The Role of Adipokines in Health and Disease

被引:199
作者
Clemente-Suarez, Vicente Javier [1 ]
Redondo-Florez, Laura [2 ]
Beltran-Velasco, Ana Isabel [3 ]
Martin-Rodriguez, Alexandra [1 ]
Martinez-Guardado, Ismael [4 ]
Navarro-Jimenez, Eduardo [5 ]
Laborde-Cardenas, Carmen Cecilia [6 ]
Tornero-Aguilera, Jose Francisco [1 ]
机构
[1] Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain
[2] Univ Europea Madrid, Fac Biomed & Hlth Sci, Dept Hlth Sci, C Tajo S-N, Madrid 28670, Spain
[3] Univ Nebrija, Fac Life & Nat Sci, Dept Psychol, Madrid 28248, Spain
[4] Univ Nebrija, Fac Life & Nat Sci, Dept Psychol, BRABE Grp, Madrid 28248, Spain
[5] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080002, Colombia
[6] Univ Simon Bolivar, Vicerrectoria Invest Innovac, Barranquilla 080005, Colombia
关键词
adipokines; inflammation; cardiovascular disease; atherosclerosis disease; mental disease; eating behavior; metabolic disease; cancer; microbiota; nutrition; physical activity; CORONARY-ARTERY-DISEASE; LIFE-STYLE MODIFICATION; WHITE ADIPOSE-TISSUE; PLASMA LEPTIN LEVELS; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; GUT MICROBIOTA; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
D O I
10.3390/biomedicines11051290
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a low-grade state of inflammation and different pathologies. The present review aims to analyze the role of adipokines in health and disease in order to understand the important functions and effects of these cytokines. For this aim, the present review delves into the type of adipocytes and the cytokines produced, as well as their functions; the relations of adipokines in inflammation and different diseases such as cardiovascular, atherosclerosis, mental diseases, metabolic disorders, cancer, and eating behaviors; and finally, the role of microbiota, nutrition, and physical activity in adipokines is discussed. This information would allow for a better understanding of these important cytokines and their effects on body organisms.
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页数:41
相关论文
共 323 条
[1]  
Abbafati C, 2020, LANCET, V396, P1204
[2]   Mixed Nut Consumption May Improve Cardiovascular Disease Risk Factors in Overweight and Obese Adults [J].
Abbaspour, Nazanin ;
Roberts, Traci ;
Hooshmand, Shirin ;
Kern, Mark ;
Hong, Mee Young .
NUTRIENTS, 2019, 11 (07)
[3]   Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction [J].
Achari, Arunkumar E. ;
Jain, Sushil K. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
[4]   Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue [J].
Agranyoni, Oryan ;
Meninger-Mordechay, Sapir ;
Uzan, Atara ;
Ziv, Oren ;
Salmon-Divon, Mali ;
Rodin, Dmitry ;
Raz, Olga ;
Koman, Igor ;
Koren, Omry ;
Pinhasov, Albert ;
Navon-Venezia, Shiri .
NPJ BIOFILMS AND MICROBIOMES, 2021, 7 (01)
[5]   IL-6 signalling pathways and the development of type 2 diabetes [J].
Akbari, Mohamad ;
Hassan-Zadeh, Vahideh .
INFLAMMOPHARMACOLOGY, 2018, 26 (03) :685-698
[6]  
Aksan G, 2014, INT J CLIN EXP MED, V7, P5461
[7]   Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers [J].
Al-muzafar, Hessah Mohammed ;
Amin, Kamal Adel .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2017, 17
[8]   Apelin levels are higher in obese patients with endometrial cancer [J].
Altinkaya, S. Ozlem ;
Nergiz, Sumeyra ;
Kucuk, Mert ;
Yuksel, Hasan .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2015, 41 (02) :294-300
[9]   Leptin resensitisation: a reversion of leptin-resistant states [J].
Andreoli, Marfa F. ;
Donato Jr, Jose ;
Cakir, Isin ;
Perello, Mario .
JOURNAL OF ENDOCRINOLOGY, 2019, 241 (03) :R81-R96
[10]  
[Anonymous], ASS PLASM ACT INH 1, DOI [10.1186/s43054-019-0012-8, DOI 10.1186/S43054-019-0012-8]