Oral Contraceptive Pills and Hypertension: A Review of Current Evidence and Recommendations

被引:17
|
作者
Cameron, Natalie A. [1 ]
Blyler, Ciantel A. [2 ]
Bello, Natalie A. [2 ,3 ]
机构
[1] Northwestern Univ, Dept Med, Div Gen Internal Med, Feinberg Sch Med, Chicago, IL USA
[2] Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol, Los Angeles, CA USA
[3] Cedars Sinai Med Ctr, Smidt Heart Inst, Dept Cardiol, 127 S San Vicente Blvd, Ste 3100, Los Angeles, CA 90048 USA
关键词
blood pressure; contraceptives; oral; estrogens; hypertension; progestins; RENIN-ANGIOTENSIN SYSTEM; ACUTE MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; YOUNG-WOMEN; RISK; DROSPIRENONE; ASSOCIATION; MULTICENTER; ESTROGEN; ESTETROL;
D O I
10.1161/HYPERTENSIONAHA.122.20018
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Oral contraceptive pills (OCPs) have been used as effective and popular forms of contraception since the middle of the last century. By 2019, over 150 million reproductive-aged individuals were using OCPs to prevent unintended pregnancies worldwide. Safety concerns regarding the effects of OCPs on blood pressure were reported soon after these pills gained approval. Although OCP doses were subsequently reduced, epidemiologic evidence continued to support a smaller, but significant association between OCPs and hypertension. Given the rising prevalence of hypertension, as well as the adverse effects of cumulative exposure to blood pressure elevations on cardiovascular disease risk, understanding the nature of the association between OCPs and hypertension is important for clinicians and patients to assess the risks and benefits of use, and make individualized decisions regarding contraception. Therefore, this review summarizes the current and historical evidence describing the association between OCP use and blood pressure elevations. Specifically, it identifies the pathophysiologic mechanisms linking OCPs to hypertension risk, describes the magnitude of the association between OCPs and blood pressure elevations, and distinguishes the effects of various OCP types on blood pressure. Finally, it describes current recommendations regarding hypertension and OCP use, as well as identifies strategies, such as over-the-counter OCP prescribing, to safely and equitably improve access to oral contraception.
引用
收藏
页码:924 / 935
页数:12
相关论文
共 50 条
  • [1] Update on oral contraceptive pills
    Cerel-Suhl, SL
    Yeager, BF
    AMERICAN FAMILY PHYSICIAN, 1999, 60 (07) : 2073 - 2084
  • [2] Evolution of Oral Contraceptive Pills
    Gandhi, Ashwini Bhalerao
    Supe, Pradnya Avinash
    JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA, 2024, 74 (02): : 109 - 112
  • [3] ORAL CONTRACEPTIVE PILLS AND OVULATION
    BURSTEIN, R
    JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1967, 202 (03): : 252 - &
  • [4] The risks of oral contraceptive pills
    Pymar, HC
    Creinin, MD
    SEMINARS IN REPRODUCTIVE MEDICINE, 2001, 19 (04) : 305 - 312
  • [5] Current Generation Oral Contraceptive Pills and Hypercoagulability: A Pilot Study.
    Pandey, S.
    Chesney, C. M.
    LABORATORY INVESTIGATION, 2011, 91 : 314A - 314A
  • [6] Current Generation Oral Contraceptive Pills and Hypercoagulability: A Pilot Study.
    Pandey, S.
    Chesney, C. M.
    MODERN PATHOLOGY, 2011, 24 : 314A - 314A
  • [7] Oral contraceptive pills and mood in adolescents
    Ott, MA
    Sayegh, MA
    Shew, ML
    Fortenberry, JD
    JOURNAL OF ADOLESCENT HEALTH, 2005, 36 (02) : 144 - 144
  • [8] Pseudoporphyria induced by oral contraceptive pills
    Silver, EA
    Silver, AH
    Silver, DS
    McCalmont, TH
    ARCHIVES OF DERMATOLOGY, 2003, 139 (02) : 227 - 228
  • [9] ANTIBIOTICS AND ORAL-CONTRACEPTIVE PILLS
    NAGER, C
    MURPHY, AA
    SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1989, 7 (03): : 220 - 223
  • [10] Risks and benefits of oral contraceptive pills
    D'Souza, RE
    Guillebaud, J
    BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2002, 16 (02) : 133 - 154