Prevalence of Gastrointestinal Symptoms and Impact on Quality of Life at 1-Year Follow-Up of Initial Attack of Acute Pancreatitis

被引:3
作者
Nasr, Alexander [1 ]
Hornung, Lindsey [2 ]
Thompson, Tyler [1 ]
Lin, Tom K. [1 ,3 ]
Vitale, David S. [1 ,3 ]
Nathan, Jaimie D. [4 ]
Varni, James W. [5 ]
Abu-El-Haija, Maisam [1 ,3 ,6 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, Cincinnati, OH USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH USA
[3] Univ Cincinnati Coll Med, Dept Pediat, Cincinnati, OH USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Pediat Gen & Thorac Surg, Cincinnati, OH USA
[5] Texas A&M Univ, Coll Med, Coll Architecture, Dept Pediat,Dept Landscape Architecture & Urban Pl, College Stn, TX USA
[6] Cincinnati Childrens Hosp Med Ctr, Pancreas Care Ctr, Div Gastroenterol Hepatol & Nutr, Pediat, 3333 Burnet Ave MLC 2010, Cincinnati, OH 45229 USA
关键词
pancreatitis; patient-reported outcomes; pediatrics; quality of life; PEDIATRIC-PATIENTS; ACUTE RECURRENT; ABDOMINAL-PAIN; WORRY SCALES; HEALTHY; RELIABILITY; CHILDREN; PEDSQL(TM)-4.0; FEASIBILITY; PREDICTORS;
D O I
10.1097/MPG.0000000000003668
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: This study aims to describe the prevalence of gastrointestinal (GI) symptoms following the first time occurrence of acute pancreatitis (AP) and to measure the impact of the episode on patient health-related quality of life (HRQOL) from the perspectives of patients and parents.Methods: Questionnaires regarding GI symptoms 1 year following the initial occurrence of AP were obtained from 74 pediatric patients. Thirty of these patients completed both the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL Gastrointestinal Symptoms and Worry Scales. These data were compared to legacy-matched healthy controls.Results: Children with a standalone occurrence of AP experienced a similar rate of GI symptoms compared to those who progressed to acute recurrent pancreatitis (ARP) within 1 year. PedsQL 4.0 Generic Core Scales scores were significantly lower for children self-report and parent proxy-report for patients that experienced AP compared to healthy controls. AP patients also demonstrated significantly more symptoms than healthy controls in the Gastrointestinal Symptoms and Worry Scales across multiple domains. Conclusions: Gastrointestinal symptoms affect many children who experience a single AP event even without recurrent attacks. The burden of symptoms is not significantly different from those who develop ARP. This is a novel study that evaluates patient-reported outcomes in children following an AP attack and demonstrates there is a significant impact on HRQOL in children and family experiences post AP. More data are needed to study the progression of disease and the extended impact of AP following an initial AP attack in pediatric patients.
引用
收藏
页码:199 / 205
页数:7
相关论文
共 40 条
  • [1] Drug induced pancreatitis is the leading known cause of first attack acute pancreatitis in children
    Abu-El-Haija, Maisam
    Hornung, Lindsey
    Lin, Tom K.
    Nathan, Jaimie D.
    Thompson, Tyler
    Vitale, David S.
    Nasr, Alexander
    Husain, Sohail Z.
    Denson, Lee
    [J]. PANCREATOLOGY, 2020, 20 (06) : 1103 - 1108
  • [2] Classification of Acute Pancreatitis in the Pediatric Population: Clinical Report From the NASPGHAN Pancreas Committee
    Abu-El-Haija, Maisam
    Kumar, Soma
    Szabo, Flora
    Werlin, Steven
    Conwell, Darwin
    Banks, Peter
    Morinville, Veronique D.
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2017, 64 (06) : 984 - 990
  • [3] What Have We Learned About Acute Pancreatitis in Children?
    Bai, Harrison X.
    Lowe, Mark E.
    Husain, Sohail Z.
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2011, 52 (03) : 262 - 270
  • [4] Cohen J., 1988, STAT POWER ANAL BEHA
  • [5] CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297, DOI DOI 10.1007/BF02310555
  • [6] Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study
    Dike, Chinenye R.
    Zimmerman, Bridget
    Zheng, Yuhua
    Wilschanski, Michael
    Werlin, Steven L.
    Troendle, David
    Shah, Uzma
    Schwarzenberg, Sarah Jane
    Pohl, John
    Perito, Emily R.
    Ooi, Chee Y.
    Nathan, Jaimie D.
    Morinville, Veronique D.
    McFerron, Brian
    Mascarenhas, Maria
    Maqbool, Asim
    Liu, Quin
    Lin, Tom K.
    Husain, Sohail Z.
    Heyman, Melvin B.
    Gonska, Tanja
    Giefer, Matthew J.
    Gariepy, Cheryl E.
    Fishman, Douglas S.
    Bellin, Melena
    Barth, Bradley
    Abu-El-Haija, Maisam
    Lowe, Mark E.
    Uc, Aliye
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2020, 71 (01) : 112 - 118
  • [7] Fairclough DL., 2002, DESIGN ANAL QUALITY
  • [8] Fayers P., 2000, QUALITY LIFE ASSESSM
  • [9] FDA, 2012, GASTR REG ENDP ADV T
  • [10] FDA Guidance for Industry, 2009, Patient-reported outcome measures: use in medical product development to support labeling claims