Investigating the transmission of baloxavir-resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study

被引：1
作者：
Harding, Joanne [1 ]
Bernasconi, Corrado [2 ]
Williams, Sarah [1 ]
Wildum, Steffen [2 ]
Kinoshita, Masahiro [3 ]
Uehara, Takeki [3 ]
Hurt, Aeron C. [2 ,4 ]
机构：
[1] Roche Prod Ltd, Welwyn Garden City, England
[2] F Hoffmann La Roche Ltd, Basel, Switzerland
[3] Shionogi & Co Ltd, Osaka, Japan
[4] F Hoffmann La Roche Ltd, Grenzacherstr 124, CH-4070 Basel, Switzerland
来源：
INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2023年 / 17卷 / 01期
关键词：
antiviral agents; baloxavir; drug resistance; influenza; transmission; viral; MARBOXIL;
D O I：
10.1111/irv.13079
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In a post-hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI-184180), we investigated household transmission of baloxavir-resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed in the study, the predicted number of PA/I38X transmission events was 4.8, assuming wild type and PA/I38X viruses were equally transmissible. However, no PA/I38X viruses were observed. These results suggest a low potential for baloxavir-resistant influenza virus transmission from treated to untreated individuals, potentially due to reduced viral/transmission fitness for PA/I38X viruses and/or low viral titres at the time when resistant viruses arise.
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页数：4
相关论文
共 13 条
  • [1] [Anonymous], 2015, Wkly Epidemiol Rec, V90, P97
  • [2] [Anonymous], 2022, STUD ASS EFF BAL MAR
  • [3] Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2)
    Baker, Jeffrey
    Block, Stanley L.
    Matharu, Balpreet
    Burleigh Macutkiewicz, Laura
    Wildum, Steffen
    Dimonaco, Sophie
    Collinson, Neil
    Clinch, Barry
    Piedra, Pedro A.
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (08) : 700 - 705
  • [4] Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents
    Hayden, Frederick G.
    Sugaya, Norio
    Hirotsu, Nobuo
    Lee, Nelson
    de Jong, Menno D.
    Hurt, Aeron C.
    Ishida, Tadashi
    Sekino, Hisakuni
    Yamada, Kota
    Portsmouth, Simon
    Kawaguchi, Keiko
    Shishido, Takao
    Arai, Masatsugu
    Tsuchiya, Kenji
    Uehara, Takeki
    Watanabe, Akira
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (10) : 913 - 923
  • [5] Understanding the Impact of Resistance to Influenza Antivirals
    Holmes, Edward C.
    Hurt, Aeron C.
    Dobbie, Zuzana
    Clinch, Barry
    Oxford, John S.
    Piedra, Pedro A.
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2021, 34 (02) : 1 - 13
  • [6] Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts
    Ikematsu, Hideyuki
    Hayden, Frederick G.
    Kawaguchi, Keiko
    Kinoshita, Masahiro
    de Jong, Menno D.
    Lee, Nelson
    Takashima, Satoru
    Noshi, Takeshi
    Tsuchiya, Kenji
    Uehara, Takeki
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) : 309 - 320
  • [7] Ison MG, 2020, LANCET INFECT DIS, V20, P1204, DOI [10.1016/S1473-3099(20)30004-9, 10.1016/51473-3099(20)30004-9]
  • [8] Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
    Lee, Leo Y. Y.
    Zhou, Jie
    Koszalka, Paulina
    Frise, Rebecca
    Farrukee, Rubaiyea
    Baba, Keiko
    Miah, Shahjahan
    Shishido, Takao
    Galiano, Monica
    Hashimoto, Takashi
    Omoto, Shinya
    Uehara, Takeki
    Mifsud, Edin J.
    Collinson, Neil
    Kuhlbusch, Klaus
    Clinch, Barry
    Wildum, Steffen
    Barclay, Wendy S.
    Hurt, Aeron C.
    [J]. PLOS PATHOGENS, 2021, 17 (05)
  • [9] NIID, 2019, DET ANT DRUG RES VIR
  • [10] In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
    Noshi, Takeshi
    Kitano, Mitsutaka
    Taniguchi, Keiichi
    Yamamoto, Atsuko
    Omoto, Shinya
    Baba, Keiko
    Hashimoto, Takashi
    Ishida, Kayo
    Kushima, Yukihiro
    Hattori, Kazunari
    Kawai, Makoto
    Yoshida, Ryu
    Kobayashi, Masanori
    Yoshinaga, Tomokazu
    Sato, Akihiko
    Okamatsu, Masatoshi
    Sakoda, Yoshihiro
    Kida, Hiroshi
    Shishido, Takao
    Naito, Akira
    [J]. ANTIVIRAL RESEARCH, 2018, 160 : 109 - 117
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