Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug

被引：1

作者：

Haritha, Vennapusa ^{[1
,2
]}

Deepthi, Pulivarthi ^{[2
]}

Gundamalla, Rachel ^{[2
]}

Nagesh, Kommu ^{[2
]}

Satyanarayana, Suggala V. ^{[3
]}

Rao, Adari Bhaskar ^{[2
]}

Balasubramanian, Sridhar ^{[4
]}

Reddy, Basireddy Venkata Subba ^{[2
]}

机构：

[1] Jawaharlal Nehru Technol Univ Anantapur, Ananthapuramu, India

[2] CSIR Indian Inst Chem Technol, Fluoro Agrochem, Hyderabad, India

[3] Jawaharlal Nehru Technol Univ Anantapur, JNTUA Coll Engn, Dept Chem Engn, Constituent Coll, Ananthapuramu, India

[4] CSIR Indian Inst Chem Technol, Ctr X Ray Crystallog, Hyderabad 500007, India

来源：

CHIRALITY | 2024年 / 36卷 / 04期

关键词：

biocatalysis; carrots; chiral alcohol; epilepsy; prochiral ketones; STEREOSELECTIVE REDUCTION; CHIRAL ALCOHOLS; PROGRESS REPORT; KETONES; VEGETABLES; ROOT;

D O I：

10.1002/chir.23660

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A green and efficient process for the synthesis of cenobamate has been accomplished in 70% yield and >99% ee through the bio-reduction of beta-ketotetrazole using Daucus carota whole plant cells. The corresponding beta-hydroxytetrazole was isolated in 60% yield and >98% ee. This is the first report on the biocatalytic reduction of beta-ketotetrazole using plant enzymes derived from D. carota root cells with excellent enantioselectivity.

引用

页数：7

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