Targeting stromal metabolism in pancreatic ductal adenocarcinoma

被引：0

作者：

Yin, Miao ^{[1
,2
,3
]}

Lei, Qun-Ying ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, State Key Lab Med Neurobiol, Inst Biomed Sci,Canc Inst,Sch Basic Med Sci,Key La, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

[4] New Cornerstone Sci Lab, Shanghai, Peoples R China

来源：

NATURE CELL BIOLOGY | 2024年 / 26卷 / 04期

关键词：

FIBROBLASTS;

D O I：

10.1038/s41556-023-01330-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumour microenvironment produces nutrients that propel cancer development. New work finds that pancreatic ductal adenocarcinoma cells use one such nutrient, acetate, to alter protein acetylation, rerouting polyamine metabolism and promoting cell growth under acidosis-a finding with potential implications for treating this cancer.

引用

页码：514 / 515

页数：2

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