Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate: A promising strategy for managing glaucoma

被引:6
作者
Maulvi, Furqan A. [1 ,2 ]
Patel, Ashmi R. [2 ]
Shetty, Kiran H. [2 ]
Desai, Ditixa T. [2 ]
Shah, Dinesh O. [3 ,4 ]
Willcox, Mark D. P. [1 ]
机构
[1] Univ New South Wales, Sch Optometry & Vis Sci, Sydney, NSW 2052, Australia
[2] Uka Tarsadia Univ, Maliba Pharm Coll, Surat 394350, India
[3] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA
[4] Univ Florida, Dept Anesthesiol, Gainesville, FL 32611 USA
关键词
Chitosan nanoparticles; Timolol maleate; Contact lens; Glaucoma; Controlled drug delivery; INTRAOCULAR-PRESSURE; EYE DROPS; LYSOZYME; RELEASE; MEDICATION;
D O I
10.1007/s13346-024-01543-8
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
To improve drug bioavailability, eye drops can be replaced by drug-eluting contact lenses. However, issues of drug leaching from lenses during manufacture and storage, and sterilization, currently limit their commercial application. To address the issues, stimuli-(lysozyme)-sensitive chitosan nanoparticles were developed to provide controlled ocular drug delivery. Nanoparticles were prepared by ionic gelation and characterized by TEM, X-ray diffraction, DSC, and FTIR. In the flux study, conventional-soaked contact lenses (SM-TM-CL) showed high-burst release, while with direct drug-only laden contact lenses (DL-TM-CL) the drug was lost during extraction and sterilization, as well as having poor swelling and optical properties. The nanoparticle-laden contact lenses (TM-Cht-NPs) showed controlled release of timolol for 120 h in the presence of lysozyme, with acceptable opto-physical properties. In the shelf-life study, the TM-Cht-NPs contact lenses showed no leaching or alteration in the drug release pattern. In animal studies, the TM-NPs-CL lenses gave a high drug concentration in rabbit tear fluid (mean = 11.01 mu g/mL for 56 h) and helped maintain a low intraocular pressure for 120 h. In conclusion, the chitosan nanoparticle-laden contact lenses demonstrated the potential application to treat glaucoma with acceptable opto-physical properties and addressed the issues of drug-leaching during sterilization and storage.
引用
收藏
页码:3212 / 3224
页数:13
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