Gut microbiota links to serum ferritin and cognition

被引:10
作者
Rosell-Diaz, Marisel [1 ,2 ,3 ]
Santos-Gonzalez, Elena [1 ,2 ,3 ]
Motger-Alberti, Anna [1 ,2 ,3 ]
Ramio-Torrenta, Lluis [4 ,5 ]
Garre-Olmo, Josep [6 ,7 ,8 ]
Perez-Brocal, Vicente [9 ,10 ]
Moya, Andres [9 ,10 ,11 ,12 ]
Jove, Mariona [13 ]
Pamplona, Reinald [13 ]
Puig, Josep [5 ,14 ,15 ,16 ]
Ramos, Rafael [5 ,17 ,18 ]
Fernandez-Real, Jose Manuel [1 ,2 ,3 ,5 ]
Mayneris-Perxachs, Jordi [1 ,2 ,3 ,19 ]
机构
[1] Dr Josep Trueta Univ Hosp, Dept Diabet Endocrinol & Nutr, Girona, Spain
[2] Girona Biomed Res Inst IDIBGI, Nutr Eumetab & Hlth Grp, Girona, Spain
[3] CIBER Ctr Invest Biomed Red Fisiopatol Obes & Nutr, Madrid, Spain
[4] Univ Girona, Dr Josep Trueta Univ Hosp, Dept Med Sci, IDIBGI,Dept Neurol,Neuroimmunol & Multiple Scleros, Girona Salt, Spain
[5] Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
[6] Girona Biomed Res Inst IDIBGI, Res Grp Hlth Gender & Aging, Girona, Spain
[7] Univ Girona, Girona, Spain
[8] Univ Girona, Dept Nursing, Girona, Spain
[9] Fdn Promot Sanit & Biomed Res Valencia Reg FISABIO, Area Genom & Hlth, Valencia, Spain
[10] Biomed Res Networking Ctr Epidemiol & Publ Hlth CI, Madrid, Spain
[11] Univ Valencia, Inst Integrat Syst Biol I2SysBio, Valencia, Spain
[12] CSIC, Valencia, Spain
[13] Univ Lleida UdL, Lleida Biomed Res Inst IRBLleida, Dept Expt Med, Lleida, Spain
[14] Parc Sanit Pere Virgili, Inst Diagnost Imaging IDI, Res Unit IDIR, Barcelona, Spain
[15] Girona Biomed Res Inst IdibGi, Med Imaging, Girona, Spain
[16] Dr Josep Trueta Univ Hosp, Gastroenterol, Girona, Spain
[17] Inst Univ Recerca Atencio Primaria Jordi Gol Gorin, Vasc Hlth Res Grp Girona ISV Girona, Jordi Gol Inst Primary Care Res, Red Invest Cronicidad,Atenc Primaria & Promoc Salu, Girona, Spain
[18] Dr Josep Trueta Univ Hosp, Girona Biomed Res Inst IDIBGI, Girona, Spain
[19] Dr Josep Trueta Univ Hosp, Dept Diabet Endocrinol & Nutr, Avinguda Franca S-N, Girona 17007, Spain
基金
欧盟地平线“2020”;
关键词
Cognition; iron stores; gut microbiota; ferritin; brain iron; epidemiology; METABOLISM; MEMORY; IMPACT;
D O I
10.1080/19490976.2023.2290318
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Iron is required for the replication and growth of almost all bacterial species and in the production of myelin and neurotransmitters. Increasing clinical studies evidence that the gut microbiota plays a critical role in iron metabolism and cognition. However, the understanding of the complex iron-microbiome-cognition crosstalk remains elusive. In a recent study in the Aging Imageomics cohort (n = 1,030), we identified a positive association of serum ferritin (SF) with executive function (EF) as inferred from the semantic verbal fluency (SVF,) the total digit span (TDS) and the phonemic verbal fluency tests (PVF). Here, we explored the potential mechanisms by analyzing the gut microbiome and plasma metabolome using shotgun metagenomics and HPLC-ESI-MS/MS, respectively. Different bacterial species belonging to the Proteobacteria phylum (Klebsiella pneumoniae, Klebsiella michiganensis, Unclassified Escherichia) were negatively associated both with SF and executive function. At the functional level, an enrichment of microbial pathways involved in phenylalanine, arginine, and proline metabolism was identified. Consistently, phenylacetylglutamine, a metabolite derived from microbial catabolism of phenylalanine, was negatively associated with SF, EF, and semantic memory. Other metabolites such as ureidobutyric acid and 19,20-DiHDPA, a DHA-derived oxylipin, were also consistently and negatively associated with SF, EF, and semantic memory, while plasma eicosapentaenoic acid was positively associated. The associations of SF with cognition could be mediated by the gut microbiome through microbial-derived metabolites.
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页数:17
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