Rh(III)-Catalyzed C-H Activation/O-Annulation for Construction of Divergent Spirosuccinimide and Maleimide-Fused Isochromenes

被引：7
|
作者：
Kamaraj, Eswaran [1 ]
Roy, Prasanta [1 ]
Lee, Yong Rok [1 ]
机构：
[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 22期
基金：
新加坡国家研究基金会;
关键词：
Rhodium; Isochromene; Maleimide; Itaconimide; C-H activation; 5+1 Annulation; CATALYZED OXIDATIVE ANNULATION; NATURAL-PRODUCTS; FUNCTIONALIZATION; DERIVATIVES; ALKYLATION; INHIBITORS; ALKALOIDS; BONDS;
D O I：
10.1002/adsc.202300803
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A rhodium-catalyzed [5+1] cycloaddition via C-H activation/O-annulation strategy for synthesizing biologically interesting isochromenes is presented. This protocol selectively provides divergently functionalized isochromenes containing spirosuccinimide and maleimide scaffolds according to the maleimides and itaconimides used as the substrates. This methodology exhibits an extensive substrate scope, remarkable functional group tolerance, and high regioselectivity.
引用
收藏
页码：3915 / 3926
页数：12
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