In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

被引：19

作者：

Li, Shifen ^{[1
]}

Zhang, Hua ^{[3
]}

Xie, Jieqi ^{[1
]}

Wang, Zhaoyi ^{[1
]}

Wang, Kai ^{[1
]}

Zhai, Zihe ^{[1
]}

Ding, Jie ^{[1
]}

Wang, Shuqin ^{[1
]}

Shen, Liyin ^{[1
]}

Wen, Jun ^{[4
,5
]}

Tang, Yi-Da ^{[4
,5
]}

Wang, Huanan ^{[3
]}

Zhu, Yang ^{[1
]}

Gao, Changyou ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Int Res Ctr X Polymers, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Shaoxing Inst, Ctr Healthcare Mat, Shaoxing 312099, Peoples R China

[3] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Peoples R China

[4] Peking Univ Third Hosp, Minist Educ, Dept Cardiol, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

[5] Peking Univ Third Hosp, Minist Educ, Inst Vasc Med, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China

来源：

MATERIALS HORIZONS | 2023年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

VISIBLE-LIGHT; OXIDATIVE STRESS; INFLAMMATION; ELASTOMERS; SCAFFOLD;

D O I：

10.1039/d3mh00594a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Advanced elastomers are highly in demand for the fabrication of medical devices for minimally invasive surgery (MIS). Herein, a shape memory and self-healing polyurethane (PCLUSe) composed of semi-crystalline poly(& epsilon;-caprolactone) (PCL) segments and interchangeable and antioxidative diselenide bonds was designed and synthesized. The excellent shape memory of PCLUSe contributed to the smooth MIS operation, leading to less surgical wounds than in the case of sternotomy. The diselenide bonds of PCLUSe contributed to the rapid self-healing under 405 nm irradiation within 60 s, and the alleviation of tissue oxidation post injury. After being delivered through a 10 mm diameter trocar onto a beating canine heart by MIS, two shape-recovered PCLUSe films self-assembled (self-healing) into a larger single patch (20 x 10 x 0.2 mm(3)) under the trigger of laser irradiation in situ, which could efficiently overcome the limited-size problem within MIS and meet a larger treatment area. The diselenide bonds in the PCLUSe cardiac patches protected the myocardium under oxidative stress post myocardial infarction (MI), and significantly maintained the cardiac functions.

引用

页码：3438 / 3449

页数：12

共 60 条

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