Natural Product Ligands of the Peroxisome Proliferator-Activated Receptor Gamma as Anti-Inflammatory Mediators

被引：2
作者：
Derangula, Madhavi [1 ]
Ruhinaz, Kumarla Kaluva [1 ]
Panati, Kalpana [2 ]
Subramani, Parasuraman Aiya [1 ]
Tatireddigari, Venkatramana Reddy Arva [1 ]
Narala, Venkata Ramireddy [1 ]
机构：
[1] Yogi Vemana Univ, Dept Zool, Kadapa 516005, Andhra Pradesh, India
[2] Govt Coll Men, Dept Biotechnol, Kadapa, Andhra Pradesh, India
来源：
NATURAL PRODUCTS JOURNAL | 2023年 / 13卷 / 06期
关键词：
Inflammation; matrix metalloproteinase; natural ligands; PPAR-gamma; peroxisome proliferator-activated receptor; anti-inflammatory mediators; NF-KAPPA-B; CONJUGATED LINOLEIC-ACID; NITRIC-OXIDE SYNTHASE; PROINFLAMMATORY CYTOKINES PRODUCTION; ENHANCES ADIPOCYTE DIFFERENTIATION; CANCER-CELL-PROLIFERATION; NITRATED FATTY-ACIDS; ACUTE LUNG INJURY; PPAR-GAMMA; GLUCOSE-UPTAKE;
D O I：
10.2174/2210315512666220907150542
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Immunologists have long considered inflammation to be a two-edged sword. Short-term inflammation can be beneficial, but long-term chronic inflammation is damaging. Obesity, type 2 diabetes (T2D), and cancer have recently been added to the never-ending list of inflammatory diseases. The nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR-?) is involved in inflammation and obesity. Clinicians employed PPAR-? agonists, both synthetic and natural, to treat disorders such as obesity and T2D without fully understanding the biochemical features and potential adverse effects. This is one of the reasons for the controversy surrounding the thiazolidinedione class of medicines, including rosiglitazone and pioglitazone. Nonetheless, various natural PPAR-? ligands, including endogenous physiological ligands, are discovered regularly around the world. This review aims to summarise the physiochemical properties and possible anti-inflammatory actions of ligands discovered in nature. Future research in this area should be supported in order to find improved commercial PPAR-? ligand anti-inflammatory products.
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页码：25 / 39
页数：15
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