Syntheses, crystal structures and Hirshfeld surface analysis of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole

被引：3
|
作者：
Okmanov, Rasul Ya. [1 ,2 ]
Ziyaev, Abdukhakim A. [1 ]
Abdukarimov, Azimboy Sh. [2 ]
Toshmurodov, Turdibek T. [1 ]
Kholikov, Tursunali S. [2 ]
机构：
[1] Acad Sci Uzbek, S Yunusov Inst Chem Plant Subst, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan
[2] Natl Univ Uzbekistan, Univ Str 4, Tashkent 100174, Uzbekistan
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2023年 / 79卷
关键词：
synthesis; 1,3,4-oxadiazole; crystal structure; Hirshfeld surface analysis; QUANTITATIVE-ANALYSIS;
D O I：
10.1107/S2056989023004164
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compounds were synthesized by alkylation of 5-[(4-dimethylamino)phenyl]-1,3,4-oxadiazole-2-thiol with benzyl chloride or 2-chloro-6-fluorobenzyl chloride in the presence of potassium carbonate. The yields of 2-(benzylsulfanyl)-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole, C17H17N3OS (I), and 2-[(2-chloro-6-fluorobenzyl)sulfanyl]-5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazole, C17H15ClFN3OS (II), were 96 and 92%, respectively. In the crystal structures of (I) and (II), C-H center dot center dot center dot pi interactions are observed between neighboring molecules. Hirshfeld surface analysis indicates that H center dot center dot center dot H and H center dot center dot center dot C/C center dot center dot center dot H interactions make the most important contributions to the crystal packing.
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收藏
页码：552 / +
页数：14
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