Association between Alcohol Intake and Prostate Cancer Mortality and Survival

被引：10

作者：

D'Ecclesiis, Oriana ^{[1
]}

Pastore, Elisa ^{[2
]}

Gandini, Sara ^{[1
]}

Caini, Saverio ^{[2
]}

Marvaso, Giulia ^{[3
,4
]}

Jereczek-Fossa, Barbara A. ^{[3
,4
]}

Corrao, Giulia ^{[4
]}

Raimondi, Sara ^{[1
]}

Bellerba, Federica ^{[1
]}

Ciceri, Silvia ^{[5
]}

Latella, Marialetizia ^{[5
]}

Cavalcabo, Nora de Bonfioli ^{[2
]}

Bendinelli, Benedetta ^{[2
]}

Saieva, Calogero ^{[2
]}

Fontana, Miriam ^{[2
]}

Gnagnarella, Patrizia ^{[5
]}

机构：

[1] IRCCS, European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

[2] Inst Canc Res Prevent & Clin Network ISPRO, Via Cosimo Vecchio 2, I-50139 Florence, Italy

[3] Univ Milan, Dept Oncol & Hemato Oncol, I-20122 Milan, Italy

[4] IRCCS, European Inst Oncol, Div Radiat Oncol, I-20141 Milan, Italy

[5] IRCCS, European Inst Oncol, Div Epidemiol & Biostat, I-20141 Milan, Italy

来源：

NUTRIENTS | 2023年 / 15卷 / 04期

关键词：

alcohol; prostate cancer; mortality; survival; Meta-analysis; LIFE-STYLE FACTORS; DRINKING PATTERNS; RISK; CONSUMPTION; COHORT; BIAS; SMOKING; MEN;

D O I：

10.3390/nu15040925

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We conducted a systematic review and meta-analysis to investigate the role of alcohol consumption with the prognosis of prostate cancer (PCa). Published reports were gathered on 15 October 2022, from PUBMED/MEDLINE and EMBASE. We found 19 independent eligible studies on the association between consumption of alcoholic beverages and the risk of fatal PCa (n = 5), PCa mortality (n = 5) in healthy subjects, and PCa patients' survival (n = 7) or surrogates thereof (n = 2). We used random effects meta-analysis to obtain a summary risk estimate (SRE) and 95% confidence intervals (95%CI) for incidence of fatal PCa and PCa mortality. The meta-analysis revealed no association between alcohol consumption and fatal prostate cancer incidence risk in healthy subjects with an indication for publication bias, but omitting the study that mainly increased the between-study heterogeneity, the SRE becomes significant (SRE 1.33, 95%CI 1.12-1.58), and the heterogeneity disappeared (I-2 = 0%) with no indication of publication bias. No association of alcohol consumption was found with mortality risk in PCa patients (SRE 0.97, 95%CI 0.92-1.03) and PCa mortality risk in healthy subjects (SRE 1.03, 95%CI 0.82-1.30). In conclusion, this study suggests that there is some evidence of an association between high alcohol consumption and an increased risk of incidence of fatal prostate cancer in healthy subjects. Given the inconsistencies this result warrants further confirmation.

引用

页数：17

共 51 条

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