Metabolic Deregulations in Patients with Polycystic Ovary Syndrome

被引:10
作者
Jabczyk, Marzena [1 ]
Nowak, Justyna [1 ]
Jagielski, Pawel [2 ]
Hudzik, Bartosz [1 ,3 ]
Kulik-Kupka, Karolina [1 ]
Wlodarczyk, Aleksander [4 ]
Lar, Katarzyna [1 ]
Zubelewicz-Szkodzinska, Barbara [1 ,5 ]
机构
[1] Med Univ Silesiaia, Fac Hlth Sci Bytom, Dept Metab Dis Prevent, PL-41900 Bytom, Poland
[2] Jagiellonian Univ Med Coll, Inst Publ Hlth, Fac Hlth Sci, Dept Nutr & Drug Res, PL-31066 Krakow, Poland
[3] Med Univ Silesiaia, Fac Med Sci Zabrze, Silesian Ctr Heart Dis, Dept Cardiol 3, PL-41800 Zabrze, Poland
[4] Dist Hosp, PL-41940 Piekary Slaskie, Poland
[5] Dist Hosp, Dept Endocrinol, PL-41940 Piekary Slaskie, Poland
关键词
polycystic ovary syndrome; atherogenic indices; anthropometric indices; metabolic disorder; LIPID-ACCUMULATION PRODUCT; INSULIN-RESISTANCE; INDEX; WOMEN; LIPOPROTEIN;
D O I
10.3390/metabo13020302
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications for women worldwide. The aim of this study was to establish the usefulness of new anthropometric indices and atherogenic indices in the evaluation of metabolic disorders, in particular, glucose and insulin abnormalities in the profiles of women with polycystic ovary syndrome (PCOS). In the study, a total of 49 women with PCOS aged between 18 and 39 years were recruited. All patients were tested for fasting glucose and insulin, lipid parameters, oral-glucose administration, and biochemical parameters. All of them underwent anthropometric measurements, such as BMI (body mass index), WHR (waist-to-hip ratio), WHtR (waist-to-height ratio), BAI (body adiposity index), VAI (visceral adiposity index), LAP (lipid accumulation product), BRI (body roundness index), ABSI (A body shape index), AIP (atherogenic risk of plasma), AC (atherogenic coefficient), Castelli risk index-I, Castelli risk index-II and (LCI) lipoprotein combine index, TG/HDL-C ratio, METS-IR (The metabolic score of insulin resistance), triglyceride glucose index (TyG index), triglyceride glucose-body mass index (TyG-BMI index) and triglyceride glucose-waist circumference index (TyG-WC index) were calculated. The analyzed anthropometric measurements/indices and atherogenic indices demonstrated significant correlations in PCOS women. T A strong relationship was found between fasting glucose, fasting insulin, glucose after 60 min, HOMA-IR index in the patients with PCOS. There was no significant relationship between HbA1c and other analyzed parameters and indices. Most of the analyzed anthropometric and atherogenic indices may be useful tools in evaluating metabolic disorders, and, in particular, glucose and insulin abnormalities in PCOS women.
引用
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页数:10
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