Complement as a Biomarker for Systemic Lupus Erythematosus

被引：47

作者：

Ayano, Masahiro ^{[1
,2
]}

Horiuchi, Takahiko ^{[3
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Canc Stem Cell Res, 3-1-1 Maidashi,Higashi ku, Fukuoka 8128582, Japan

[3] Kyushu Univ, Beppu Hosp, Dept Internal Med, 4546 Tsurumibaru, Tsurumi 8740838, Japan

来源：

BIOMOLECULES | 2023年 / 13卷 / 02期

关键词：

systemic lupus erythematosus; lupus nephritis; complement; split product; cell-bound complement activation product; serological activity; DISEASE-ACTIVITY INDEX; DIAGNOSTIC PERFORMANCE; ACTIVATION PRODUCTS; INITIAL VALIDATION; NEPHRITIS; C4D; CLASSIFICATION; COMPONENT; C1Q; C3;

D O I：

10.3390/biom13020367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systemic lupus erythematosus (SLE) is a disease of immune complex deposition; therefore, complement plays a vital role in the pathogenesis of SLE. In general, complement levels in blood and complement deposition in histological tests are used for the management of SLE. Thus, the evaluation of complement status can be useful in the diagnosis of SLE, assessment of disease activity, and prediction of treatment response and prognosis. In addition, novel complement biomarkers, such as split products and cell-bound complement activation products, are considered to be more sensitive than traditional complement markers, such as serum C3 and C4 levels and total complement activity (CH50), which become more widely used. In this review, we report the complement testing in the management of SLE over the last decade and summarize their utility.

引用

页数：14

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