Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice

被引：17

作者：

Li, Lu-Yao ^{[1
,2
,3
]}

Wang, Qi ^{[2
,3
]}

Deng, Lu ^{[2
,4
]}

Lin, Zhen ^{[2
,5
]}

Lin, Jing-Jing ^{[2
,6
]}

Wang, Xin-Ye ^{[2
,3
]}

Shen, Tian-Yang ^{[2
,3
]}

Zheng, Yi-Hui ^{[2
,3
]}

Lin, Wei ^{[2
,3
]}

Li, Pei-Jun ^{[2
,4
]}

Fu, Xiao-Qin ^{[2
,3
]}

Lin, Zhen-Lang ^{[2
,3
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 2, Dept Neonatol, Wenzhou, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 2, Dept Geriatr, Wenzhou, Zhejiang, Peoples R China

[5] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthoped, Wenzhou, Zhejiang, Peoples R China

[6] Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Wenzhou, Zhejiang, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

chlorogenic acid; ferroptosis; glutathione peroxidase 4; lipid peroxidation; neonatal hypoxic-ischemic brain injury; neurons; neuroprotection; oxidative stress; oxygen-glucose deprivation; system Xc(-); CELL-DEATH; OXIDATIVE STRESS; THERAPEUTIC HYPOTHERMIA; REDOX BIOLOGY; RAT MODEL; ENCEPHALOPATHY; FERROPTOSIS; METABOLISM; BIOMARKERS; SPECTROSCOPY;

D O I：

10.4103/1673-5374.350203

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have shown that chlorogenic acid (CGA), which is present in coffee, has protective effects on the nervous system. However, its role in neonatal hypoxic-ischemic brain injury remains unclear. In this study, we established a newborn mouse model of hypoxic-ischemic brain injury using a modified Rice-Vannucci method and performed intraperitoneal injection of CGA. We found that CGA intervention effectively reduced the volume of cerebral infarct, alleviated cerebral edema, restored brain tissue structure after injury, and promoted axon growth in injured brain tissue. Moreover, CGA pretreatment alleviated oxygen-glucose deprivation damage of primary neurons and promoted neuron survival. In addition, changes in ferroptosis-related proteins caused by hypoxic-ischemic brain injury were partially reversed by CGA. Furthermore, CGA intervention upregulated the expression of the key ferroptosis factor glutathione peroxidase 4 and its upstream glutamate/cystine antiporter related factors SLC7A11 and SLC3A2. In summary, our findings reveal that CGA alleviates hypoxic-ischemic brain injury in neonatal mice by reducing ferroptosis, providing new ideas for the treatment of neonatal hypoxic-ischemic brain injury.

引用

页码：568 / 576

页数：9

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