Immature platelet fraction in cardiovascular diagnostics and antiplatelet therapy monitoring

被引：5

作者：

Gumiezna, Karolina ^{[1
]}

Barus, Piotr ^{[1
]}

Sygitowicz, Grazyna ^{[2
]}

Wisniewska, Agnieszka ^{[3
]}

Ochijewicz, Dorota ^{[1
]}

Pasierb, Karolina ^{[1
]}

Klimczak-Tomaniak, Dominika ^{[4
,5
]}

Kuca-Warnawin, Ewa ^{[6
]}

Kochman, Janusz ^{[1
]}

Grabowski, Marcin ^{[1
]}

Opolski, Grzegorz ^{[1
]}

Tomaniak, Mariusz ^{[1
,7
]}

Filipiak, Krzysztof J. ^{[1
]}

机构：

[1] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland

[2] Med Univ Warsaw, Dept Clin Chem & Lab Diagnost, Warsaw, Poland

[3] Med Univ Warsaw, Dept Lab Diagnost, Warsaw, Poland

[4] Med Univ Warsaw, Dept Cardiol Hypertens & Internal Med, Warsaw, Poland

[5] Med Univ Warsaw, Dept Immunol Transplantat & Internal Med, Warsaw, Poland

[6] Natl Inst Geriatr Rheumatol & Rehabil, Dept Pathophysiol & Immunol, Warsaw, Poland

[7] Med Univ Warsaw, Dept Cardiol 1, Ul Banacha 1a, PL-02097 Warsaw, Poland

来源：

CARDIOLOGY JOURNAL | 2023年 / 30卷 / 05期

关键词：

immature platelet fraction; antiplatelet therapy monitoring; acute coronary syndromes; CORONARY-ARTERY-DISEASE; RETICULATED PLATELETS; STENT THROMBOSIS; INFARCT SIZE; TURNOVER; VOLUME; AGGREGATION; PREDICTORS; REACTIVITY; ASPIRIN;

D O I：

10.5603/CJ.a2023.0019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immature platelet fraction (IPF), circulating platelets still containing RNA, can be easily calculated by automated flow cytometry, this makes them an accessible biomarker. Higher IPF concentrations were reported in patients with thrombocytopenia, patients who were smokers, and also those who were diabetics. Several studies have reported their diagnostic and prognostic importance in patients presenting with acute coronary syndromes, especially ST-segment elevation myocardial infarction, where increased IPF level is an independent predictor of cardiovascular death. In addition, higher IPF were reported in patients with inadequate response to either clopidogrel or prasugrel, suggesting their potential role in antiplatelet therapy monitoring. Their prognostic significance was also observed in both coronary artery disease and postcardiac surgery status, where their higher levels correlated with the risk of major adverse cardiac events.The current review aims to present the current evidence on diagnostic, prognostic and potentially therapeutic roles of IPF in cardiovascular medicine. (Cardiol J 2023; 30, 5: 817-824)

引用

页码：817 / 824

页数：8

共 43 条

[1] Immature platelets as a novel biomarker for adverse cardiovascular events in patients after non-cardiac surgery [J].