Progress in Glucose-Sensitive Hydrogels for Biomedical Applications

被引：6
|
作者：
Li, Yaxun [1 ,2 ]
Feng, Guoqin [1 ,2 ]
Liu, Jiajia [1 ,2 ]
Yang, Tingting [1 ,2 ]
Hou, Ruxia [1 ,2 ]
Liu, Junyu [1 ,2 ]
Wang, Xiangyu [1 ,2 ]
机构：
[1] Shanxi Med Univ, Sch & Hosp Stomatol, Taiyuan 030001, Peoples R China
[2] Shanxi Prov Key Lab Oral Dis Prevent & New Mat, Taiyuan 030001, Peoples R China
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2023年 / 224卷 / 23期
基金：
中国国家自然科学基金;
关键词：
biomedicals; glucose-sensitive; hydrogels; DIABETES-MELLITUS; INSULIN; COMPLICATIONS; THERAPY; POLYSACCHARIDE; NANOPARTICLES; LIRAGLUTIDE; CHALLENGES; DRESSINGS; DELIVERY;
D O I：
10.1002/macp.202300257
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Diabetes mellitus is one of the key diseases of clinical concern that can lead to a variety of serious complications and it is characterized by increased blood glucose levels. Glucose-sensitive hydrogel is gaining attention as a smart hydrogel capable of sensing glucose molecules for diabetes and related complications. In order to better understand this hydrogel, this paper reviews its basic design principles and focuses on the therapeutic efficacy of this hydrogel in delivering insulin, drugs, and bioactives for diabetes and diabetes-related complications. Its use as a biosensing device for glucose measurement in body fluids and dynamic monitoring of wounds is also presented, and its potential application in the treatment of diabetes and related diseases is highly summarized. This review provides an overview of glucose sensitive hydrogel basic design principles and therapeutic efficacy in delivering insulin, drugs, and bioactives for diabetes and diabetes-related complications. Its use as a biosensing device for glucose dynamic monitoring is presented, and its potential application in the treatment of diabetes and related diseases is highly summarized. image
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页数：13
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