Comparative Analysis of Heart Regeneration: Searching for the Key to Heal the Heart-Part I: Experimental Injury Models to Study Cardiac Regeneration

被引:2
作者
Castillo-Casas, Juan Manuel [1 ]
Cano-Carrillo, Sheila [1 ]
Sanchez-Fernandez, Cristina [1 ,2 ]
Franco, Diego [1 ,2 ]
Lozano-Velasco, Estefania [1 ,2 ]
机构
[1] Univ Jaen, Dept Expt Biol, Cardiovasc Dev Grp, Jaen 23071, Spain
[2] Medina Fdn, Granada 18007, Spain
关键词
cardiac disease; myocardial infarction; molecular pathways; hypoxia; metabolism; inflammation; cell cycle; fibrosis; heart regeneration; ACUTE MYOCARDIAL-INFARCTION; NEONATAL MOUSE HEART; REPERFUSION INJURY; CORONARY-ARTERY; NEWT HEARTS; ADULT; ZEBRAFISH; VITRO; ISCHEMIA; CAPACITY;
D O I
10.3390/jcdd10080325
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiovascular diseases are the leading cause of death worldwide, among which, ischemic heart disease is the most prevalent. Myocardial infarction results from occlusion of a coronary artery, which leads to an insufficient blood supply to the myocardium. As is well known, the massive loss of cardiomyocytes cannot be solved due the limited regenerative ability of the adult mammalian heart. In contrast, some lower vertebrate species can regenerate the heart after injury; their study has disclosed some of the involved cell types, molecular mechanisms and signaling pathways during the regenerative process. In this two-part review, we discuss the current state of the principal response in heart regeneration, where several involved processes are essential for full cardiac function in recovery.
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页数:10
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