The alleviating effect of ellagic acid on DSS-induced colitis via regulating gut microbiomes and gene expression of colonic epithelial cells

被引：0

作者：

Li, Xiaoqing ^{[1
,2
]}

Xu, Lu ^{[1
]}

Peng, Xinan ^{[1
]}

Zhang, Huiting ^{[1
]}

Kang, Meng ^{[1
]}

Jiang, Yiqi ^{[1
]}

Shi, Haibo ^{[2
]}

Chen, Haiyan ^{[5
]}

Zhao, Chao ^{[4
]}

Yu, Yigang ^{[2
]}

Ma, Ruiting ^{[3
]}

Li, Xueli ^{[3
]}

Cao, Yong ^{[1
]}

机构：

[1] South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Nutraceut & Funct Foods, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China

[2] South China Univ Technol, Coll Food Sci & Engn, Guangzhou 510006, Peoples R China

[3] Eastroc Beverage Grp Co Ltd, Shenzhen 518057, Peoples R China

[4] Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Peoples R China

[5] Guangdong Testing Inst Prod Qual Supervis GQI, Foshan 528300, Peoples R China

来源：

FOOD & FUNCTION | 2023年 / 14卷 / 16期

关键词：

INFLAMMATORY-BOWEL-DISEASE; INTESTINAL BARRIER FUNCTION; OXIDATIVE STRESS; EXTRACT; CANCER; MICE;

D O I：

10.1039/d3fo01226c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The anti-inflammatory effect of ellagic acid (EA) and its possible underlying mechanism in dextran sulfate sodium (DSS)-induced mouse chronic colonic inflammation were studied. It was observed that EA administration significantly alleviated the colonic inflammation phenotypes, including decreasing the disease activity index (DAI), enhancing the body weight loss, and improving the shortened length of the colon and pathological damage of colon tissue. Additionally, EA reshaped the constitution of the gut microbiota by elevating the ratio of Bacteroidetes along with Bacteroides and Muribaculaceae, while decreasing the proportion of Firmicutes. The Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2) revealed that the metabolic function of the gut microbiota was also changed. Furthermore, mouse colon transcriptome analysis showed that the tight junction and peroxisome proliferator-activated receptor (PPAR) signaling pathways were activated and the expressions of related genes were upregulated after EA intervention. These results showed that EA could remodel the gut bacterial composition, change the intestinal epithelial cell gene expressions in mice, and consequently improve the colonic inflammatory symptoms.

引用

页码：7550 / 7561

页数：12

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