Prognostic impact of cardiohepatic syndrome in patients with ST-segment elevation myocardial infarction

被引：0
作者：
Sungur, Mustafa A. [1 ]
Sungur, Aylin [2 ]
Karagoz, Ali [3 ]
Can, Fatma [1 ]
Yilmaz, Mehmet F. [1 ]
Zeren, Gonul [1 ]
Avci, Ilhan I. [1 ]
Yumurtas, Ahmet C. [1 ]
Tanboga, Ibrahim H. [4 ]
Karabay, Can Y. [1 ]
机构：
[1] Dr Siyami Ersek Thorac & Cardiovasc Surg Educ Res, Dept Cardiol, Selimiye Mh Tibbiye Cd 25,Uskudar, Istanbul, Turkiye
[2] Sureyyapasa Chest Dis & Thorac Surg Training & Re, Dept Cardiol, Basibuyuk Mh Sureyyapasa Yerleskesi, Istanbul, Turkiye
[3] Kartal Kosuyolu Heart Training & Res Hosp, Dept Cardiol, Denizer Cd Cevizli Kavsagi 2 Kartal, Istanbul, Turkiye
[4] Nisantasi Univ, Dept Cardiol, Saray Mh Site Yolu Cd 7 Umraniye, Istanbul, Turkiye
来源：
BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 02期
关键词：
cardiohepatic syndrome; in-hospital mortality; long-term mortality; ST-segment elevation myocardial infarction; GAMMA-GLUTAMYL-TRANSFERASE; SERUM ALKALINE-PHOSPHATASE; IN-HOSPITAL MACE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MORTALITY; RISK; GUIDELINES; PREDICTOR; BILIRUBIN;
D O I：
10.2217/bmm-2022-0770
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Cardiohepatic syndrome (CHS) indicates a bidirectional interaction between the heart and liver. This study was designed to evaluate the impact of CHS on in-hospital and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention. Materials & methods: 1541 consecutive STEMI patients were examined. CHS was defined as the elevation of at least two of three cholestatic liver enzymes: total bilirubin, alkaline phosphatase and gamma-glutamyl transferase. Results: CHS was present in 144 (9.34%) patients. Multivariate analyses revealed CHS as an independent predictor of in-hospital (odds ratio: 2.48; 95% CI: 1.42-4.34; p = 0.001) and long-term mortality (hazard ratio: 2.4; 95% CI: 1.79-3.22; p < 0.001). Conclusion: The presence of CHS is a predictor of poor prognosis in patients with STEMI and should be evaluated during the risk stratification of these patients.
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页码：111 / 121
页数：11
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