The Role of Exosomes in Human Carcinogenesis and Cancer Therapy-Recent Findings from Molecular and Clinical Research

被引：29

作者：

Stefanska, Katarzyna ^{[1
,2
]}

Jozkowiak, Malgorzata ^{[3
]}

Angelova Volponi, Ana ^{[4
]}

Shibli, Jamil Awad ^{[5
]}

Golkar-Narenji, Afsaneh ^{[6
]}

Antosik, Pawel ^{[7
]}

Bukowska, Dorota ^{[8
]}

Piotrowska-Kempisty, Hanna ^{[3
,9
]}

Mozdziak, Paul ^{[6
]}

Dziegiel, Piotr ^{[10
]}

Podhorska-Okolow, Marzenna ^{[11
]}

Zabel, Maciej ^{[10
,12
]}

Dyszkiewicz-Konwinska, Marta ^{[13
]}

Kempisty, Bartosz ^{[6
,7
,14
,15
]}

机构：

[1] Poznan Univ Med Sci, Dept Histol & Embryol, PL-60781 Poznan, Poland

[2] Cellivia 3 SA, PL-61623 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Toxicol, PL-60631 Poznan, Poland

[4] Kings Coll London, Dent Inst, Ctr Craniofacial & Regenerat Biol, London WC2R, England

[5] Univ Guarulhos, Dept Periodontol & Oral Implantol, BR-07030010 Guarulhos, Brazil

[6] North Carolina State Univ, Prestage Dept Poultry Sci, Raleigh, NC 27695 USA

[7] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Vet Surg, PL-87100 Torun, Poland

[8] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Diagnost & Clin Sci, PL-87100 Torun, Poland

[9] Nicolaus Copernicus Univ Torun, Inst Vet Med, Dept Basic & Preclin Sci, PL-87100 Torun, Poland

[10] Wroclaw Med Univ, Dept Human Morphol & Embryol, Div Histol & Embryol, PL-50368 Wroclaw, Poland

[11] Wroclaw Med Univ, Dept Human Morphol & Embryol, Div Ultrastruct Res, PL-50368 Wroclaw, Poland

[12] Univ Zielona Gora, Div Anat & Histol, PL-65046 Zielona Gora, Poland

[13] Poznan Univ Med Sci, Dept Biomat & Expt Dent, PL-60812 Poznan, Poland

[14] Wroclaw Med Univ, Dept Human Morphol & Embryol, Div Anat, PL-50368 Wroclaw, Poland

[15] Masaryk Univ, Univ Hosp, Dept Obstet & Gynecol, Brno 60177, Czech Republic

来源：

CELLS | 2023年 / 12卷 / 03期

基金：

美国食品与农业研究所;

关键词：

exosomes; cancer; drug resistance; cancer therapies; TUMOR-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; IN-VITRO; CELLS; DNA; EXPRESSION; SECRETION; KRAS; IDENTIFICATION; ANGIOGENESIS;

D O I：

10.3390/cells12030356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40-160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.

引用

页数：22

共 45 条

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