Independent and combined associations of polycyclic aromatic hydrocarbons exposure and sleep disorders among adults in the US adult population

被引:4
作者
Zhao, Hui [1 ,2 ]
Fang, Lanlan [1 ,2 ]
Chen, Yuting [1 ,2 ]
Ni, Jianping [1 ,2 ]
Chen, Xuyang [1 ,2 ]
Pan, Faming [1 ,2 ,3 ]
机构
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China
[2] Anhui Med Univ, Inflammat & Immune Mediated Dis Lab Anhui Prov, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
Polycyclic aromatic hydrocarbons; Co-exposure; Combined effect; Sleep disorders; NHANES; BIOMARKERS; POLLUTION; DURATION; BRAIN; PAHS;
D O I
10.1016/j.jad.2024.01.111
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Polycyclic aromatic hydrocarbons (PAHs) are prevalent organic pollutants in the environment; however, limited research has been conducted to explore their potential effects on sleep disorders. This study aims to investigate the relationship between single and mixed PAHs exposures and sleep disorders. Methods: This study analyzed National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2016, involving 7730 adult participants. To examine the relationship between PAHs exposure and sleep disorders, we employed survey-weighted multivariate logistic regression models and restricted cubic spline (RCS) models to evaluate single PAHs exposure. Additionally, we employed three mixed-exposure models to examine the relationship between combined PAHs exposure and sleep disorders. Results: After adjusting for covariates, our analyses revealed positive associations between several urinary PAHs metabolites (1-hydroxynaphthalene (1-NAP), 2-NAP, 3-hydroxyfluorene (3-FLU), 2-FLU, and 1-hydroxypyrene (1-PYR)) and sleep disturbance. Consistency across various analytical methods underscores a discernible positive correlation between simultaneous exposure to PAHs and sleep disorders. This association is predominantly influenced by the presence of NAP and FLU. Remarkably, a positive relationship between combined PAHs exposure and sleep disorders emerged within the younger and middle-aged demographic but did not manifest within the elderly population. Conclusion: In conclusion, our study provides new epidemiological evidence suggesting that both single and mixed PAHs exposures may increase the risk of sleep disorders. Further prospective investigations are necessary to validate these findings.
引用
收藏
页码:319 / 327
页数:9
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