A quantitative description of the compatibility of technetium-selective chromatographic technetium-99m separation with low specific activity molybdenum-99

被引：1
作者：
Jang, Jaewoong [1 ,2 ]
Sekimoto, Shun [3 ]
Ohtsuki, Tsutomu [3 ]
Tatenuma, Katsuyoshi [4 ]
Tsuguchi, Akira [4 ]
Uesaka, Mitsuru [1 ,5 ]
机构：
[1] Univ Tokyo, Sch Engn, Dept Bioengn, 7-3-1 Hongo, Bunkyo, Tokyo 1138656, Japan
[2] Univ Tokyo, Isotope Sci Ctr, 2-11-16 Yayoi, Bunkyo, Tokyo 1130032, Japan
[3] Kyoto Univ, Inst Integrated Radiat & Nucl Sci, 2-1010 Asashironishi, Sennan, Osaka 5900494, Japan
[4] Kaken Inc, 1044 Hori, Mito, Ibaraki 3100903, Japan
[5] Univ Tokyo, Nucl Profess Sch, Sch Engn, 2-22 Shirakata Shirane, Naka, Ibaraki 3191188, Japan
来源：
JOURNAL OF CHROMATOGRAPHY A | 2023年 / 1705卷
关键词：
Chromatographic separation; Molybdenum-99; Technetium-99m; Activity concentration; Specific activity; ACTIVATED CARBON; PERTECHNETATE; PURIFICATION; EFFICIENT; RECOVERY; SORPTION; SURFACE; FUTURE; COLUMN;
D O I：
10.1016/j.chroma.2023.464192
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Technetium-99m generators employing a technetium-selective stationary phase are a chromatographic instrument developed for use with 99Mo having low specific activity (LSA); particularly, 99Mo produced by electron accelerators. This paper presents a mathematical description of technetium-selective chromatographic (TSC) 99mTc separation and analyzes its compatibility with LSA 99Mo. We developed a theoretical formula for TSC 99mTc separation by discretizing its pertechnetate selectivity, and validated it using an electron linear accelerator and activated carbon-based TSC (AC-TSC) 99mTc generators. We confirmed that the activity concentration of 99mTc obtained from a TSC 99mTc generator can be calculated directly from its input 99Mo activity regardless of the 99Mo specific activity. The formula corroborates that TSC 99mTc separation is compatible with LSA 99Mo, and has a practical application in estimating the number of TSC 99mTc generators required for 99mTc demand of interest.& COPY; 2023 Elsevier B.V. All rights reserved.
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页数：10
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