Palladium-Catalyzed Alkenyl C-H Activation/Diamination toward Tetrahydrocarbazole and Analogs Using Hydroxylamines as Single- Nitrogen Sources

被引：9
作者：
Han, Lingbo [1 ]
Liu, Tingjie [1 ]
Wang, Han [1 ]
Luan, Xinjun [1 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol, Minist Educ, Xian 710127, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 01期
基金：
中国国家自然科学基金;
关键词：
N BOND FORMATION; INDOLE ALKALOIDS; AMINO SOURCES; AMIDATION; AMINATION; ARYL; AZIRIDINATION; CYCLIZATIONS; ACIDS;
D O I：
10.1021/acs.orglett.2c03809
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed alkenyl C-H activation/ diamination reaction of cycloalkenyl bromoarenes with hydroxyl-amines is described. A wide range of tetrahydrocarbazoles and analogs has been prepared using fine-tuning bifunctional secondary hydroxylamines as the single-nitrogen sources. Mechanistic investigations suggest that the selective alkenyl C-H activation/ diamination cascade process should build the N-heterocycles.
引用
收藏
页码：58 / 63
页数：6
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