Cardiac multiscale bioimaging: from nano- through micro- to mesoscales

被引：4
作者：
Tolstik, Elen [1 ]
Lehnart, Stephan E. [2 ,3 ,4 ]
Soeller, Christian [5 ]
Lorenz, Kristina [1 ,6 ]
Sacconi, Leonardo [7 ,8 ]
机构：
[1] Leibniz Inst Analyt Wissensch ISAS eV, Dept Cardiovasc Pharmacol Translat Res, Bunsen Kirchhoff Str 11, D-44139 Dortmund, Germany
[2] Georg August Univ Gottingen, Heart Res Ctr Gottingen, Dept Cardiol & Pneumol, Univ Med Ctr Gottingen,Cellular Biophys & Translat, Robert Koch Str 42a, D-37075 Gottingen, Germany
[3] Univ Gottingen, Cluster Excellence Multiscale Bioimaging Mol Machi, D-37073 Gottingen, Germany
[4] Univ Gottingen, Collaborat Res Ctr SFB1190 Compartmental Gates & C, D-37073 Gottingen, Germany
[5] Univ Bern, Dept Physiol, Buhlpl 5, CH-3012 Bern, Switzerland
[6] Univ Wurzburg, Inst Pharmacol & Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany
[7] CNR, Inst Clin Physiol, Rome, Italy
[8] Univ Freiburg, Inst Expt Cardiovasc Med, Elsasser Str 2q, D-79110 Freiburg, Germany
来源：
TRENDS IN BIOTECHNOLOGY | 2024年 / 42卷 / 02期
基金：
瑞士国家科学基金会;
关键词：
RAMAN-SPECTROSCOPY; RESOLUTION; HEART; REDISTRIBUTION; TISSUE;
D O I：
10.1016/j.tibtech.2023.08.007
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive understanding of the heart and its functions at various levels, from the molecular to the entire organ. It combines both physiologically and clinically relevant dimensions: from nano- and micrometer resolution imaging based on vibrational spectroscopy and high -resolution microscopy to assess molecular processes in cardiac cells and myocardial tissue, to mesoscale structural investigations to improve the understanding of cardiac (patho)physiology. Tailored superresolution deep microscopy with advanced proteomic methods and hands-on experience are thus strategically combined to improve the quality of cardiovascular research and support future medical decision -making by gaining additional biomolecular information for translational and diagnostic applications.
引用
收藏
页码：212 / 227
页数：16
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