Circulating melatonin is elevated in women with polycystic ovary syndrome (PCOS); whether circadian disruptions coincide with sleep disturbances in women with PCOS or their symptom severity is unclear. The objective of this observational pilot study was to determine whether altered patterns of melatonin excretion are associated with reduced sleep quality in women with versus without PCOS. Participants underwent a clinical assessment, transvaginal ultrasound, and reproductive hormone testing. Morning and evening urine samples were assayed for urinary 6-sulfatoxymelatonin (MEL) as a proxy for melatonin production. The night (morning MEL)-to-day (evening MEL) ratio, or N:D ratio, was determined to approximate the rhythm of MEL production. Sleep quality and duration were assessed using the Pittsburgh Sleep Quality Index (PSQI) and wrist actigraphy. No differences were detected in overnight MEL, daytime MEL, or the N:D ratio in participants with PCOS versus controls. The PCOS group experienced reduced weekend sleep efficiency vs. controls (81% vs. 88% p < 0.05). The number of follicles per ovary (FNPO) was positively associated with overnight MEL (r = 0.359, p < 0.05). Weekend sleep time and overnight MEL concentrations were dependent on PCOS status. Therefore, diagnostic features of PCOS were associated with MEL production and sleep disturbances, suggesting that women with a more severe clinical presentation of PCOS may be more likely to experience altered MEL production or sleep disturbances.
机构:
Univ Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
Univ Teknol MARA UiTM, Maternofetal & Embryo Res Grp MatE, Bandar Puncak Alam 40450, Selangor, MalaysiaUniv Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
Mutalip, Siti Syairah Mohd
Nordin, Massita
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Univ Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, MalaysiaUniv Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
Nordin, Massita
Mohamed, Ruzianisra
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Univ Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, MalaysiaUniv Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
Mohamed, Ruzianisra
Siew, John Shia Kwong
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Univ Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, MalaysiaUniv Teknol MARA UiTM, Dept Pharmaceut Life Sci, Fac Pharm, Bandar Puncak Alam 42300, Selangor, Malaysia
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Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA
Tidwell, Anna
Zhu, Jia
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Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA
Zhu, Jia
Battiola, Tess
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Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA
Battiola, Tess
Welt, Corrine K.
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Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USAUniv Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA