Fifteen-year clinical prognosis and cardiovascular or limb event associated with homocysteine levels in peripheral arterial disease

被引:2
作者
Kumakura, Hisao [1 ,3 ]
Funada, Ryuichi [1 ]
Matsuo, Yae [1 ]
Iwasaki, Toshiya [1 ]
Nakashima, Kuniki [2 ]
Tsuboi, Eitoshi [2 ]
Ichikawa, Shuichi [1 ]
机构
[1] Kitakanto Cardiovasc Hosp, Cardiovasc Hosp Cent Japan, Dept Cardiovasc Med, Shibukawa, Gunma, Japan
[2] Kitakanto Cardiovasc Hosp, Dept Cardiovasc Surg, Cardiovasc Hosp Cent Japan, Shibukawa, Gunma, Japan
[3] Shimohakoda 740 Hokkitu Machi, Shibukawa city, Gunma 3770061, Japan
关键词
Homocysteine; All-cause mortality; Major adverse cardiovascular event; Limb events; Peripheral arterial disease; DENSITY-LIPOPROTEIN CHOLESTEROL; LONG-TERM SURVIVAL; NATRIURETIC PEPTIDE; KIDNEY-DISEASE; RISK-FACTOR; IMPACT; SERUM; SCORE;
D O I
10.1016/j.jjcc.2023.04.021
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: There are limited reports on the relationship between plasma homocysteine (Hcy) levels and longterm all-cause death (ACD), cardiovascular events, or limb events in patients with peripheral arterial disease (PAD). We examined the relationship between plasma Hcy levels and 15-year these events in PAD patients. Methods: We performed a prospective cohort study in 955 PAD patients. The patients were divided into four groups based on plasma Hcy levels with median (interquartile range). The endpoints were cumulative incidences of ACD, major adverse cardiovascular events (MACE), and MACE plus limb events (MACLE). Results: The incidences of ACD, MACE, and MACLE were correlated with plasma Hcy levels (P < 0.05). In multiple regression analysis, plasma Hcy had positive correlations with C-reactive protein (CRP), men, and critical limb ischemia (CLI) and negative correlations with estimated glomerular filtration rate (eGFR) and high-density lipoprotein cholesterol (p < 0.05). In Cox multivariate analysis, higher Hcy (HR 1.614, 95 % CI 1.229-2.119, p = 0.001), age, CRP, brain natriuretic peptide (BNP), D-dimer, lower body mass index, ankle brachial pressure index (ABI), serum albumin, eGFR, CLI, coronary heart disease (CHD), cerebrovascular disease, and diabetes were related to ACD; higher Hcy (HR 1.242, 95 % CI 1.004-1.535, p = 0.045), age, BNP, lower ABI, serum albumin, diabetes, and CHD were related to MACE; and higher Hcy (HR 1.290, 95 % CI 1.057-1.574, p = 0.012), BNP, lower ABI, serum albumin, CHD, and diabetes were related to MACLE (P < 0.05). Statins improved ACD, MACE, and MACLE (p < 0.01). Conclusions: Plasma Hcy was a risk factor for 15-year ACD, MACE, and MACLE in patients with PAD. (c) 2023 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:423 / 428
页数:6
相关论文
共 32 条
[1]   Impact of peripheral artery disease on prognosis after myocardial infarction: The J-MINUET study [J].
Akahori, Hirokuni ;
Masuyama, Tohru ;
Imanaka, Takahiro ;
Nakao, Koichi ;
Ozaki, Yukio ;
Kimura, Kazuo ;
Ako, Junya ;
Noguchi, Teruo ;
Suwa, Satoru ;
Fujimoto, Kazuteru ;
Nakama, Yasuharu ;
Morita, Takashi ;
Shimizu, Wataru ;
Saito, Yoshihiko ;
Hirohata, Atsushi ;
Morita, Yasuhiro ;
Inoue, Teruo ;
Okamura, Atsunori ;
Mano, Toshiaki ;
Hirata, Kazuhito ;
Tanabe, Kengo ;
Shibata, Yoshisato ;
Owa, Mafumi ;
Tsujita, Kenichi ;
Funayama, Hiroshi ;
Kokubu, Nobuaki ;
Kozuma, Ken ;
Uemura, Shiro ;
Tobaru, Tetsuya ;
Saku, Keijiro ;
Oshima, Shigeru ;
Nishimura, Kunihiro ;
Miyamoto, Yoshihiro ;
Ogawa, Hisao ;
Ishihara, Masaharu .
JOURNAL OF CARDIOLOGY, 2020, 76 (04) :402-406
[2]   Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials [J].
Antoniades, Charalambos ;
Antonopoulos, Alexios S. ;
Tousoulis, Dimitris ;
Marinou, Kyriakoula ;
Stefanadis, Christodoulos .
EUROPEAN HEART JOURNAL, 2009, 30 (01) :6-15
[3]   A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].
BOUSHEY, CJ ;
BERESFORD, SAA ;
OMENN, GS ;
MOTULSKY, AG .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13) :1049-1057
[4]  
Cacoub Patrice P, 2009, Atherosclerosis, V204, pe86, DOI 10.1016/j.atherosclerosis.2008.10.023
[5]   Homocysteine and risk of ischemic heart disease and stroke -: A meta-analysis [J].
Clarke, R ;
Collins, R ;
Lewington, S ;
Donald, A ;
Alfthan, G ;
Tuomilehto, J ;
Arnesen, E ;
Bonaa, K ;
Blacher, J ;
Boers, GHJ ;
Bostom, A ;
Bots, ML ;
Grobee, DE ;
Brattström, L ;
Breteler, MMB ;
Hofman, A ;
Chambers, JC ;
Kooner, JS ;
Coull, BM ;
Evans, RW ;
Kuller, LH ;
Evers, S ;
Folsom, AR ;
Freyburger, G ;
Parrot, F ;
Genst, J ;
Dalery, K ;
Graham, IM ;
Daly, L ;
Hoogeveen, EK ;
Kostense, PJ ;
Stehouwer, CDA ;
Hopknis, PN ;
Jacques, P ;
Selhub, J ;
Luft, FC ;
Jungers, P ;
Lindgren, A ;
Lolin, YI ;
Loehrer, F ;
Fowler, B ;
Mansoor, MA ;
Malinow, MR ;
Ducimetiere, P ;
Nygard, O ;
Refsum, H ;
Vollset, SE ;
Ueland, PM ;
Omenn, GS ;
Beresford, SAA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (16) :2015-2022
[6]   Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine β-synthase-deficient mice [J].
Dayal, S ;
Bottiglieri, T ;
Arning, E ;
Maeda, N ;
Malinow, MR ;
Sigmund, CD ;
Heistad, DD ;
Faraci, FM ;
Lentz, SR .
CIRCULATION RESEARCH, 2001, 88 (11) :1203-1209
[7]   Factors explaining the difference of total homocysteine between men and women in the European investigation into cancer and nutrition Potsdam study [J].
Dierkes, J ;
Jeckel, A ;
Ambrosch, A ;
Westphal, S ;
Luley, C ;
Boeing, H .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2001, 50 (06) :640-645
[8]  
Friedman AN, 2001, J AM SOC NEPHROL, V12, P2181, DOI 10.1681/ASN.V12102181
[9]   Mass spectrometry evidence for formation of estrogen-homocysteine conjugates: Estrogens can regulate homocysteine levels [J].
Gaikwad, Nilesh W. .
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 65 :1447-1454
[10]   Levels and clinical significance of serum homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), vaspin, and visfatin in elderly patients with different types of coronary heart disease [J].
Guan, Jing ;
Wu, Li ;
Xiao, Qian ;
Pan, Li .
ANNALS OF PALLIATIVE MEDICINE, 2021, 10 (05) :5679-5686