Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer

被引：1

作者：

Waldum, Helge ^{[1
]}

机构：

[1] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Clin & Mol Med, Trondheim, Norway

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

von Hippel Lindau factor; hypoxia inducible factor (HIF); renal cancer; prolyl hydroxylase inhibitor (roxadustat); renal anemia; erythropoietin producing cell; ERYTHROPOIETIN; EXPRESSION;

D O I：

10.3389/fphar.2023.1170796

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页数：2

共 2 条

[1] Hypoxia-inducible Factor 2-Dependent Pathways Driving von Hippel-Lindau-Deficient Renal Cancer
Melendez-Rodriguez, Florinda
Roche, Olga
Sanchez-Prieto, Ricardo
Aragones, Julian
FRONTIERS IN ONCOLOGY, 2018, 8
[2] Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition
Chintala, Sreenivasulu
Najrana, Tanbir
Toth, Karoly
Cao, Shousong
Durrani, Farukh A.
Pili, Roberto
Rustum, Youcef M.
BMC CANCER, 2012, 12

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