Clinico-Pathogenic Similarities and Differences between Infection-Related Glomerulonephritis and C3 Glomerulopathy

被引:5
作者
Wada, Yukihiro [1 ]
Kamata, Mariko [1 ]
Miyasaka, Ryoma [1 ]
Abe, Tetsuya [1 ]
Kawamura, Sayumi [1 ]
Takeuchi, Kazuhiro [1 ]
Aoyama, Togo [1 ]
Oda, Takashi [2 ]
Takeuchi, Yasuo [1 ]
机构
[1] Kitasato Univ, Sch Med, Dept Nephrol, 1-15-1 Kitasato,Minami Ku, Sagamihara, Kanagawa 2520374, Japan
[2] Tokyo Med Univ Hachioji Med Ctr, Kidney Dis Ctr, Dept Nephrol & Blood Purificat, Tokyo 1930998, Japan
关键词
infection-related glomerulonephritis; C3; glomerulopathy; membranoproliferative glomerulonephritis; nephritis-associated plasmin receptor; complement alternative pathway; DENSE DEPOSIT DISEASE; MEMBRANOUS-LIKE GLOMERULOPATHY; HEMOLYTIC-UREMIC SYNDROME; POSTINFECTIOUS GLOMERULONEPHRITIS; STREPTOCOCCUS-PYOGENES; PLASMIN RECEPTOR; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; POSTSTREPTOCOCCAL GLOMERULONEPHRITIS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; COMPLEMENT ABNORMALITIES;
D O I
10.3390/ijms24098432
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recently, the comprehensive concept of "infection-related glomerulonephritis (IRGN)" has replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection patterns, epidemiology, clinical features, and pathogenesis. In addition to evidence of infection, hypocomplementemia particularly depresses serum complement 3 (C3), with endocapillary proliferative and exudative GN developing into membranoproliferative glomerulonephritis (MPGN); also, C3-dominant or co-dominant glomerular immunofluorescence staining is central for diagnosing IRGN. Moreover, nephritis-associated plasmin receptor (NAPlr), originally isolated from the cytoplasmic fraction of group A Streptococci, is vital as an essential inducer of C3-dominant glomerular injury and is a key diagnostic biomarker for IRGN. Meanwhile, "C3 glomerulopathy (C3G)", also showing a histological pattern of MPGN due to acquired or genetic dysregulation of the complement alternative pathway (AP), mimics C3-dominant IRGN. Initially, C3G was characterized by intensive "isolated C3" deposition on glomeruli. However, updated definitions allow for glomerular deposition of other complement factors or immunoglobulins if C3 positivity is dominant and at least two orders of magnitude greater than any other immunoreactant, which makes it challenging to quickly distinguish pathomorphological findings between IRGN and C3G. As for NAPlr, it was demonstrated to induce complement AP activation directly in vitro, and it aggravates glomerular injury in the development of IRGN. A recent report identified anti-factor B autoantibodies as a contributing factor for complement AP activation in pediatric patients with PIGN. Moreover, C3G with glomerular NAPlr deposition without evidence of infection was reported. Taken together, the clinico-pathogenic features of IRGN overlap considerably with those of C3G. In this review, similarities and differences between the two diseases are highlighted.
引用
收藏
页数:14
相关论文
共 78 条
[11]   Update on C3 Glomerulopathy: A Complement-Mediated Disease [J].
Caravaca-Fontan, Fernando ;
Lucientes, Laura ;
Cavero, Teresa ;
Praga, Manuel .
NEPHRON, 2020, 144 (06) :272-280
[12]   Anti-Factor B Antibodies and Acute Postinfectious GN in Children [J].
Chauvet, Sophie ;
Berthaud, Romain ;
Devriese, Magali ;
Mignotet, Morgane ;
Martins, Paula Vieira ;
Robe-Rybkine, Tania ;
Miteva, Maria A. ;
Gyulkhandanyan, Aram ;
Ryckewaert, Amelie ;
Louillet, Ferielle ;
Merieau, Elodie ;
Mestrallet, Guillaume ;
Rousset-Rouviere, Caroline ;
Thervet, Eric ;
Hogan, Julien ;
Ulinski, Tim ;
Villoutreix, Bruno O. ;
Roumenina, Lubka ;
Boyer, Olivia ;
Fremeaux-Bacchi, Veronique .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (04) :829-840
[13]   The etiology of glomerulonephritis: roles of infection and autoimmunity [J].
Couser, William G. ;
Johnson, Richard J. .
KIDNEY INTERNATIONAL, 2014, 86 (05) :905-914
[14]   Atypical Infection-Related Glomerulonephritis With "Masked" IgG-Kappa Crystalline Hump-Like Deposits [J].
DiFranza, Lanny T. ;
Markowitz, Glen S. ;
D'Agati, Vivette D. ;
Santoriello, Dominick .
KIDNEY INTERNATIONAL REPORTS, 2021, 6 (01) :228-233
[15]   EPIDEMIC ACUTE GLOMERULONEPHRITIS ASSOCIATED WITH TYPE-49 STREPTOCOCCAL PYODERMA .1. CLINICAL AND LABORATORY FINDINGS [J].
KAPLAN, EL ;
ANTHONY, BF ;
CHAPMAN, SS .
AMERICAN JOURNAL OF MEDICINE, 1970, 48 (01) :9-&
[16]   Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference [J].
Goodship, Timothy H. J. ;
Cook, H. Terence ;
Fakhouri, Fadi ;
Fervenza, Fernando C. ;
Fremeaux-Bacchi, Veronique ;
Kavanagh, David ;
Nester, Carla M. ;
Noris, Marina ;
Pickering, Matthew C. ;
de Cordoba, Santiago Rodriguez ;
Roumenina, Lubka T. ;
Sethi, Sanjeev ;
Smith, Richard J. H. .
KIDNEY INTERNATIONAL, 2017, 91 (03) :539-551
[17]   C3 glomerulopathy: Understanding an ultra-rare complement-mediated renal disease [J].
Heiderscheit, Amanda K. ;
Hauer, Jill J. ;
Smith, Richard J. H. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 2022, 190 (03) :344-357
[18]   Glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma pneumoniae induces infection-related glomerulonephritis [J].
Hirano, Daishi ;
Oda, Takashi ;
Ito, Akira ;
Yamada, Akifumi ;
Kakegawa, Daisuke ;
Miwa, Saori ;
Umeda, Chisato ;
Takemasa, Yoichi ;
Tokunaga, Ai ;
Wajima, Takeaki ;
Nakaminami, Hidemasa ;
Noguchi, Norihisa ;
Ida, Hiroyuki .
CLINICAL NEPHROLOGY, 2019, 92 (05) :263-272
[19]   Toward a working definition of C3 glomerulopathy by immunofluorescence [J].
Hou, Jean ;
Markowitz, Glen S. ;
Bomback, Andrew S. ;
Appel, Gerald B. ;
Herlitz, Leal C. ;
Stokes, M. Barry ;
D'Agati, Vivette D. .
KIDNEY INTERNATIONAL, 2014, 85 (02) :450-456
[20]   Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome [J].
Iatropoulos, Paraskevas ;
Noris, Marina ;
Mele, Caterina ;
Piras, Rossella ;
Valoti, Elisabetta ;
Bresin, Elena ;
Curreri, Manuela ;
Mondo, Elena ;
Zito, Anna ;
Gamba, Sara ;
Bettoni, Serena ;
Murer, Luisa ;
Fremeaux-Bacchi, Veronique ;
Vivarelli, Marina ;
Emma, Francesco ;
Daina, Erica ;
Remuzzi, Giuseppe .
MOLECULAR IMMUNOLOGY, 2016, 71 :131-142