Three-Component Fusion to Pyrazolo[5,1-a]isoquinolines via Rh- Catalyzed Multiple Order Transformation of Enaminones

被引：27

作者：

Chen, Demao ^{[1
]}

Wan, Changfeng ^{[1
]}

Liu, Yunyun ^{[1
]}

Wan, Jie-Ping ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

[2] Nanjing Forestry Univ, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; BOND FORMATION; ANNULATION; ALKYNES; AMIDATION; AMINES;

D O I：

10.1021/acs.joc.3c00019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and practical method for the synthesis of fused tricyclic pyrazolo[5,1-a]isoquinolines has been realized via the reactions of enaminones, hydrazine hydrochloride, and internal alkynes. By means of Rh catalysis, the extraordinary high-order bond functionalization, including the transformation of aryl C-H, ketone C=O, and alkenyl C-N bonds in the enaminones, marks the major feature of the cascade reactions. The results disclose the individual advantage of enaminones in the design of novel and efficient synthetic methods.

引用

页码：4833 / 4838

页数：6

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