This paper investigates the link between the non-profit sector and regional well-being, conceiving and measuring the latter following a multidimensional approach that considers several factors affecting the quality of life of populations. A cross-sectional econometric analysis conducted on a sample of 106 Italian provinces shows findings robust to several specifications and scenarios consistent with our hypothesis that the non-profit sector constitutes, thanks to its key ability to produce relational goods, a driver of regional well-being.